Early Diabetes

Advances in Metabolic Disorders, Supplement 1: Early Diabetes covers the discussions during the first International Symposium on Early Diabetes. The book discusses the views of the role of genetic factors in diabetes; the genetic problem posed by the relatively high frequency of diabetes; the relationship between diabetes and prediabetes in the mother; and the congenital defect in the offspring. The text also describes the report on the genetics of diabetes among the Pima Indians, as well as the genetics of animals with spontaneous diabetes. The pathophysiology of diabetes mellitus, the concept of progression from prediabetes to chemical diabetes and then to overt diabetes, and the effect of aging on carbohydrate metabolism are also considered. The book further tackles the epidemiology of early diabetes, as well as the natural history of diabetes. The text concludes by looking into the treatment of early diabetes, including topics on insulin treatment of children with a late stage of chemical diabetes; complementary arguments in favor of the betacytotrophic action of the hypoglycemic sulphonamides; and the use of oral hypoglycemic compounds. Endocrinologists, biochemists, physiologists, and researchers working on the treatment of diabetes will find the book invaluable.

List of ContributorsForewordPrefaceI. Genetics of Diabetes The Genetics of Diabetes Mellitus Preliminary Report on the Genetics of Diabetes among the Pima Indians Genetics of Animals with Spontaneous Diabetes DiscussionII. Pathophysiology Some Factors Controlling Differentiation and/or Modulation of Rat Pancreatic Islet Cells A Two-Compartmental Model for Insulin Secretion Mechanisms in the Control of Insulin Release by Glucose and Other Substances The Mechanism of Insulin Secretion Studied through the Effects of Electrolytes and Inhibitors Discussion Insulin Secretion in Early Diabetic Animals: In Vivo Studies Diabetogenesis The Effect of ß-Adrenergic Receptor Blocking Agents on Drug-Induced Insulin Secretion Dynamics of Insulin Secretion in Early Diabetes in Humans Evidence that the Primary Lesion in Familial Diabetes Mellitus is an Inherited Defect of the ß-Cell Subnormal Secretion of Insulin in Mild Diabetes Mellitus Discussion Possible Role of Insulin-Stimulating Hormones in Disturbances of Nutrient Tolerance Invited Discussant Discussion Evidence for an Abnormal Insulin in Diabetes Mellitus Metabolism of Insulin in Normal and Diabetic Subjects A Postulated Mechanism for the Insulin Synergistic and Insulin Antagonistic Action of Growth Hormone Human Proinsulin: Some Considerations in the Development of a Specific Immunoassay Discussion Does Diabetes Begin with Insulin Resistance? Does Diabetes Begin with Insulin Resistance? Invited Discussants Discussion The Critical Role of Obesity in the Interpretation of Serum Insulin Levels Invited Discussant DiscussionIII. Maternal-Placental-Fetal Relationship Metabolic Realignments in Late Pregnancy: A Clue to Diabetogenesis Invited Discussant Discussion Fetuses and Newborns of 95% Pancreatectomized Female Rats Offspring of Animals with Experimental Diabetes Discussion Infants of the Diabetic Mother Invited Discussants DiscussionIV. Prediabetes and Chemical or Latent Diabetes Early Stages of the Diabetic State: Definitions and Concepts Discussion Further Electron Microscopic Studies of Diabetic Microangiopathy Diagnostic Criteria in the Assessment of Glomerular Capillary Basement Membrane Lesions in Newly Diagnosed Juvenile Diabetics Variations in Capillary Basement Membrane Width Produced by Aging and Diabetes Mellitus Invited Discussant Discussion Influence of Weight upon Serum Insulin and the Serum Growth Hormone Responses of Male Offspring of Two Diabetic Parents Biochemical and Functional Abnormalities in Prediabetic Subjects Metabolic Studies in Prediabetic Subjects Prospective Diagnosis of Diabetes Invited Discussants Discussion Gestational Diabetes and Its Significance Invited Discussant DiscussionV. Effect of Aging on Carbohydrate Metabolism Effect of Aging on Carbohydrate MetabolismVI. The Epidemiology of Early Diabetes The Epidemiology of Early Diabetes Hyperglycemia and Vascular Disease in Tecumseh, Michigan Invited Discussant DiscussionVII. Natural History of Diabetes The Course of Asymptomatic Diabetes of Children, Adolescents. and Young Adults Natural History of Diabetes DiscussionVIII.