Experimental Chemotherapy

Experimental Chemotherapy, Volume I, attempts to condense the existing knowledge in the broad field of experimental chemotherapy in a comprehensive form. The arrangement of the subject matter follows a plan by which the not always avoidable repetitive description is reduced to a minimum. In most of the protozoan and metazoan infections it appeared advantageous to discuss the different series of active compounds according to the specific diseases and their causative agents. In other cases, owing to the wide range of activity of certain antibacterials, the material is arranged according to the groups of compounds. This first volume deals with infections caused by parasites, both protozoan and metazoan; it also contains general chapters on history of chemotherapy, toxicology, statistics, and drug resistance. It is hoped that the treatise will be useful to experimental workers engaged in the search for new chemotherapeutic remedies and in the study of their mechanism of action; to all who are involved in the teaching of pharmacology and therapeutics; and to physicians and veterinarians interested in the experimental basis of the drugs they are using.

ContributorsPreface1. History of Chemotherapy I. Introduction II. Early Development by Ehrlich (Trypanosomes and Spirochetes) III. Compounds against Malaria and Other Parasitic Infections IV. Statistics V. Achievements Up to 1930 VI. Sulfonamides VII. Antibiotics VIII. Position of Chemotherapy IX. Analysis of Chemotherapeutic Research X. Conclusion References2. Toxicity in Chemotherapy I. Introduction II. Acute Toxicity III. Prolonged Toxicity IV. Unpredictable Toxicities V. Conclusion Appendix: Dose and Animal Size References3. Statistical Evaluation in Chemotherapy I. Introduction II. General Considerations III. Variability IV. Distribution V. History VI. Types of Response VII. The Quantal Response VIII. The Quantitative Response IX. Relative Activity X. The Screening of New Compounds Summary of Symbols Used References4. Drug Resistance in Chemotherapy I. Introduction II. Development of Resistant Forms III. Attributes of Drug Resistance IV. Mechanism of Drug Resistance V. Drug Dependence VI. Origin of Drug Resistance VII. Drug Antagonism and Synergism: Relation to Drug Resistance VIII. General Considerations References5. Chemotherapy of Trypanosomiasis Part 1: Principles and Techniques I. Basic Biological Principles II. Techniques for Measuring Chemotherapeutic Activity Part 2: Chemotherapeutic Effects of Active Compounds I. Arsenicals II. Antimonials III. Acridine Compounds IV. Suramin V. Diamidines VI. Phenanthridinium Compounds VII. Quinaldine and Quinoline Derivatives VIII. Furans and Nitrofurans IX. Triphenylmethane Dyes X. Antibiotics XI. Miscellaneous Part 3 : Mechanism of Activity of Drugs on Trypanosomes I. Types of Trypanocidal Activity II. Fixation of Drug by Trypanosomes III. Secondary Chemical Reactions between the Drug and Cell Constituents IV. Response of the Cell to Injury, i.e. Death V. Drug Resistance in Trypanosomes VI. Antagonism VII. Photosensitization VIII. Role of Reticuloendothelial System References6. Chemotherapy of Leishmaniasis I. Basic Biological Principles II. General Techniques for Measuring Chemotherapeutic Activity III. Chemotherapeutic Effects of Active Compounds References7. Chemotherapy of Trichomonad Infections I. Basic Biological Principles II. Chemotherapeutic Activity III. General Considerations References8. Chemotherapy of Histomoniasis I. Basic Biological Principles II. General Techniques for Measuring Chemotherapeutic Activity III. Active Compounds IV. Mode of Action of Drugs against Histomonas References9. Chemotherapy of Giardiasis I. Biological Principles II. Laboratory Studies III. Clinical References10. Chemotherapy of Amebiasis I. Basic Biological Principles II. General Techniques for Measuring Chemotherapeutic Activity III. Chemotherapeutic Agents against Entamoeba histolytica IV. Principles of Mechanism of Activity Acknowledgments References11. Chemotherapy of Coccidiosis I. Basic Biological Principles II. General Techniques for Measuring Chemotherapeutic Activity III. Active Compounds IV. Mechanism of Coccidistatic Activity References12. Chemotherapy of Malaria Part 1: Biological Basis of Testing Methods I. Introduction II. General Biological Principles III. Evaluation of Antimalarial Activity Part 2: The Antimalarial Drugs I. Chemotherapeutic Effects of the Specifically Active Compounds II. Principles of Mechanism of Activity References13. Chemotherapy of Babesiasis I. Basic Biological Principles II.