High-LET Radiations in Clinical Radiotherapy

High-LET Radiations in Clinical Radiotherapy covers the proceedings of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and other High-LET Particles in Clinical Radiotherapy. The title presents papers that report the experiences in utilizing High-LET radiations in clinical radiotherapy. The coverage of the text includes observations on the reactions of normal and malignant tissues to a standard dose; and clinical observations of early and late normal tissue injury and tumor control in patients receiving fast neutron irradiation. The selection also covers results of fast neutron radiotherapy at Amsterdam; and results of clinical applications with fast neutrons in Edinburgh. The book will be of great use to students and practitioners of medical technology.

Introduction to the ProceedingsSessions I and II. Reports on Clinical Experience Second Preliminary Report of the M. D. Anderson Study of Neutron Therapy for Locally Advanced Gynecological Tumors Observations on the Reactions of Normal and Malignant Tissues to a Standard Dose of Neutrons Results of Fast Neutron Radiotherapy at Amsterdam Results of Fast Neutron Beam Radiotherapy Pilot Studies at the University of Washington Results of Clinical Applications with Fast Neutrons in Edinburgh Fast Neutron Project at Fermilab Clinical Observations of Early and Late Normal Tissue Injury and Tumor Control in Patients Receiving Fast Neutron Irradiation Results of Clinical Applications of Fast Neutrons at Hamburg-Eppendorf Results of Clinical Applications of Negative Pions at Los Alamos Results of Tumor Treatments with Alpha Particles and Heavy Ions at Lawrence Berkeley Laboratory Results of Clinical Applications of Fast Neutrons in Japan Five Years of Clinical Experience with a Combination of Neutrons and Photons Hyperbaric Oxygen and Hypoxic Cell Sensitizers in Clinical Radiotherapy: Present State and Prospects Treatment at Low Dose Rate, by Low-LET Radiation: Present Status and Prospects Combined Chemo/Radiotherapy of Cancer: Present State and Prospects for Use with High-LET RadiotherapySessions III and IV. Physical Aspects and Radiobiology Review of Performance of High-LET Radiation Sources Used in Clinical Applications Dose Distributions of Clinical Fast Neutron Beams Dosimetry Intercomparisons and Protocols for Therapeutic Applications of Fast Neutron Beams Characteristics of Fast Neutron Sources Contributions on Characteristics of Fast Neutron Sources Neutron Dosimetry, Radiation Quality and Biological Dosimetry Contributions on Neutron Dosimetry, Radiation Quality and Biological Dosimetry Review of RBE Data for Cells in Culture RBE Values of Fast Neutrons for Responses of Experimental Tumors Neutron RBE for Normal Tissues Fast Neutron Radiobiology Contributions on fast Neutron Radiobiology Dosimetry and Radiobiology of Negative Pions and Heavy Ions Contributions on Dosimetry and Radiobiology of Negative Pions and Deavy Ions The Committee on Radiation Oncology Studies Plan for a Program in Particle Therapy in the United StatesSessions V and VI. Evaluation of Present Results and Future of High LET Radiotherapy Evaluation of Clinical Experience Concerning Evaluation of Tumor Response to High-LET Radiation Evaluation of Normal Tissue Responses to High-LET Radiations The Application of RBE Values to Clinical Trials of High-LET Radiations Doses and Fractionation Schemes to Be Employed in Clinical Trials of High-LET Radiations Review of Protocols for High-LET Radiotherapy in the United States Clinical Trials with Fast Neutrons in Europe Summary of Discussion on Multi-Center Collaboration in Clinical Trials with High-LET Radiations Concluding Remarks on the Future of High-LET RadiotherapyList of Participants of the 3rd Meeting on Fundamental and Practical Aspects of the Application of Fast Neutrons and Other High-LET Particles in Clinical Radiotherapy