Hormones and Atherosclerosis

Hormones and Atherosclerosis covers the proceedings of the conference held in Brighton, Utah on March 11-14, 1958. The book focuses on the role of hormones in atherosclerosis, as well as cholesterol metabolism and biosynthesis, lipogenesis, and lipid transport. The selection first discusses the biosynthesis of cholesterol and aspects of the biosynthesis of cholesterol from mevalonic acid. Discussions focus on components of liver homogenates and coenzymes required for squalene and sterol synthesis from mevalonic acid and preservation of enzymes and microsomes. The text also ponders on the formation and metabolism of bile acids under different conditions and thyroid function, thyroxine analogs, and cholesterol metabolism in rats and rabbits. The book elaborates on the comparison of the participations of fibroblasts and reticuloendothelial cells in the synthesis and metabolism of cortisol and cholesterol and control of aortal lipid metabolism and lipid movement by hormones and vitamins. The manuscript also examines the influence of estrogens on lipids and atherosclerosis in experimental animals and the effect of adrenals, pituitary, liver, and mucopolysaccharides on blood lipids. The selection is a dependable reference for readers interested in the relationship of hormones and atherosclerosis.

List of ContributorsConference MembershipPreface1. Biosynthesis of Cholesterol2. Some Aspects of the Biosynthesis of Cholesterol from Mevalonic Acid Discussion of Chapters 1 and 23. The Formation and Metabolism of Bile Acids under Different Conditions Discussion4. Thyroid Function, Thyroxine Analogs, and Cholesterol Metabolism in Rats and Rabbits Discussion5. The Conversion of C14-Acetate to Cholesterol in the Euthyroid and Hypothyroid Dog Discussion6. The Relationship between Thyroid Hormones and Cholesterol, Biosynthesis and Turnover7. Methyltestosterone and the Thyroid Discussion of Chapters 6 and 78. A Comparison of the Participations of Fibroblasts and Reticuloendothelial Cells in the Synthesis and Metabolism of Cortisol and Cholesterol Discussion9. Influence of Hormones on Lipid Biosynthesis in Liver Discussion10. The Arterial Wall as an Organ11. Control of Aortal Lipid Metabolism and Lipid Movement by Hormones and Vitamins Discussion12. Phospholipid Turnover in Atheromatous Lesions Discussion13. Isotopic Studies of Cholesterol Metabolism in Man Discussion14. Influences of Thyroid, Pancreatic, and Adrenal Hormones on Lipid Metabolism and Atherosclerosis in Experimental Animals Discussion15. Adrenocortical Hormones and Experimental Atherosclerosis Discussion16. Experimental Stress, Blood Lipids, and Atherosclerosis Discussion17. Experimental Atherosclerosis in Dogs Discussion18. Influence of Estrogens on Lipids and Atherosclerosis in Experimental Animals Discussion19. Effect of New Steroids on Blood Lipids Discussion20. Effect of Adrenals, Pituitary, Liver, and Mucopolysaccharides on Blood Lipids Discussion21. The Possible Relationship of the Emotions to Clinical Coronary Heart Disease Discussion22. Influences of Hormones on Circulating Lipids Discussion23. Effect of Desiccated Thyroid Substance and Thyroid Congeners upon Serum Lipoproteins and Serum Cholesterol Levels Discussion24. The Effects of Sex Hormones on Serum Lipids and Lipoproteins Discussion25. Modification of the Effects of Adrenal Cortical Steroids and Androgens on Serum Lipids and Lipoproteins by Caloric Supplementation and by Isocaloric Substitution of Carbohydrate for Dietary Protein Discussion26. Prediction of Estrogenic Side Effects of Steroids in Man Discussion27. Approaches to the Problem of the Relation of Emotions to Hormonal Function and Atherosclerosis Discussion28. Some Aspects of the Endocrinological Picture of the South African Bantu-A Population Relatively Free from Mortality from Coronary Disease Discussion29. Thyroid and Estrogen Treatment of Hypercholesterolemia in Man Discussion30. Interim Report on Clinical Experiences with Long-Term Estrogen Administration to Middle-Aged Men with Coronary Heart Disease31. Studies with Manvene32. Hormonal Treatment in Arteriosclerotic Disease DiscussionAuthor IndexSubject Index

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