Inhaled Particles and Vapours

Inhaled Particles and Vapors covers the proceedings of an International Symposium by the same title on September 28 - October 1, 1965, organized by the British Occupational Hygiene Society. This book is organized into seven sections encompassing 48 chapters. Section I reviews the anatomy and physiology of human lung. Section II describes the pulmonary response to dust in terms of airway changes and reactions to silica. Sections III and IV deal with lung clearance in animals, the retention, penetration, and elimination of inhaled dusts, and lung deposition and clearance in human. Section V emphasizes the sources of dust inhaled by the human lungs, while Section VI discusses the relationship between pneumonoconiosis and dust exposure. Section VII presents the results of the investigations of dust exposure. This book will prove useful to pulmonologists, toxicologists, and workers in the field of occupational health.

PrefaceSection I. Anatomy and Physiology Utilisation du Chat dans l'Étude Expérimentale des Pneumoconioses Discussion Continuous Monitoring of Cardiopulmonary Parameters in Laboratory Animals Fatty Acid Synthesis by Subcellular Fractions of Lung Tissue Discussion Mucociliary Particle Clearance in the Human Nose Discussion A Study of Volumes of Respired Air in Relation to Dust Exposures of Coal Miners Discussion An Intra-Pulmonary Route of Dust Elimination In Rats DiscussionSection IIA. Pulmonary Response to Dust - Airway Changes Location and Mechanism of Airway Constriction After Inhalation of Histamine Aerosol and Inorganic Sulfate Aerosol Discussion Histamine Release by Compound 48/80 and Textile Dusts from Lung Tissue in Vitro The Effect of Cotton Dust on Respiratory Mechanics in Man and in Guinea Pigs Discussion Reaction of the Lungs to Various Broncho-Irritating Substances DiscussionSection IIB. Pulmonary Response to Dust - Reactions to Silica Tissue Reaction to Different Types of Amorphous Silica Discussion Silicotic Bronchiolitis Obliterans - A Focal Clearance Failure Discussion Some Biologically Active Substances Produced by the Action of Silica and their Possible Significance Discussion Observations on the Cytotoxic Action of Silica on Macrophages DiscussionSection IIC. Pulmonary Response to Dust - Miscellaneous The Pulmonary Response of Rats to Fluorspar Dust and Radiation Tissue Reactions in Rat Lungs After Dust Inhalation Discussion Recherches Infrastructurales sur l'Évolution des Macrophages Alvéolaires et Leurs Réactions Aux Poussières Minérales DiscussionSection III. Lung Clearance in Animals Alveolar Clearance: Its Relation to Lesions of the Respiratory Bronchiole Discussion The Alveolar Clearance Mechanism of Retained Particles Discussion Short-Term Lung Clearance in Rabbits Exposed to a Radioactive Bidisperse (6 and 3 µ) Polystyrene Aerosol Discussion Comparison of Dust Retention in Specific Pathogen Free and Standard Rats Discussion Retention, Penetration And Elimination of Inhaled Dusts Discussion Mechanisms of Resistance To Bacterial Infection in the Lung Discussion Reactions of Alveolar Phagocytes to Aerosols During Short-Term Exposure to Dust Discussion Pulmonary Clearance of 59Fe203 and 51Cr2CO3 in Rats and Dogs Exposed to Cigarette Smoke Discussion Biological Studies Associated with a Field Release of Plutonium Discussion Non-Equilibrium Tissue Distributions of Uranium and Thorium Following Inhalation of Uranium Ore by Rats Discussion Ciliary Activity and Histologie Observations in the Trachea After Exposure to Ammonia and Carbon ParticlesSection IV. Lung Deposition and Clearance in Man A Study of the Retention and Subsequent Metabolism of Inhaled Methyl Iodide Discussion Regional Aerosol Deposition in the Human Respiratory Tract Discussion Deposition of Aerosols in the Human Respiratory Tract During Breath-Holding Discussion The Clearance of Dust from the Lower Respiratory Tract of Man. An Experimental Study Discussion The Clearance of Radioactive Particles from the Human Lung DiscussionSection V. Dust in Human Lungs Grain Size and Mineral Content of Lung Dust of Coal Miners Compared with Mine Dust Discussion Airborne Dust in Coal Mines: The Particle-Size-Selection Characteristics of the Lung and the Desirable Characteristics of Dust-Sampling Instruments Discussion Quantitative Studies of Dust Retention in Animal and Human Lungs After Chronic Inhalation Discussion Dust Content, Radiology and Pathology in Simple Pneumoconiosis of Coalworkers Discussion Fate of Submicronic Inhaled Dust in the LungsSection VI.