International Review of Experimental Pathology

International Review of Experimental Pathology, Volume 30, is organized around the theme of renal disease. The choice of renal disease reflects both the author's personal interest and the realization that there is a need for such a collection of reviews in this area. There are many new books on renal pathology, but almost all have a clinical rather than experimental orientation. The book opens with a chapter on the pathogenesis of experimentally induced renal papillary necrosis and upper urothelial carcinoma. Subsequent chapters deal with the use of cell cultures in the study of renal diseases; mechanisms of cyclosporine nephrotoxicity in humans and animal systems; spontaneously occurring renal diseases in laboratory animals; and the use of video microscopy to define the reactivity of the renal microvasculature and the hydraulic permeability of the glomerular capillaries. This book will be of interest to a diverse group of readers interested in renal disease. This broad spectrum of potential readership is reflected in the list of contributors which includes, in addition to pathologists, nephrologists, anatomists, veterinarians, and experimental chemists. This volume will also be of interest to transplant surgeons and to pediatricians specializing in renal disease.

PrefaceExperimentally Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma I. Introduction II. Renal Papillary Necrosis and Upper Urothelial Carcinoma in Humans III. Experimentally Induced Renal Papillary Necrosis IV. Use of Model Papillotoxic Probes to Study the Pathogenesis and Secondary Development of Renal Papillary Necrosis V. Biochemical Interpretation of the Pathogenesis and Secondary Consequences of Renal Papillary Necrosis VI. Renal Papillary Necrosis and Upper Urothelial Carcinoma VII. Summary of the Pathogenesis of Experimentally Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma VIII. Remaining Questions ReferencesThe Contribution of Cell Culture to the Study of Renal Diseases I. Introduction II. Glomerular Cell Culture III. Tubular Cell Culture ReferencesCyclosporine Nephrotoxicity I. Introduction II. Experimental Models of Cyclosporine Nephrotoxicity III. Clinical Cyclosporine Nephrotoxicity IV. Future Directions and Unanswered Questions ReferencesGlomerular Antigens in Experimental Glomerulonephritis I. Models of Glomerulonephritis II. Structure and Function of the Glomerulus III. Immune Mechanisms in the Pathogenesis of Glomerulonephritis IV Antigens in Experimental Glomerulonephritis V Genetic Influences VI. Conclusion ReferencesSpontaneous Renal Disease in Laboratory Animals I. Introduction II. Rat III. Mouse IV. Hamster V Rabbit VI. Guinea Pig VII. Dog VIII. Monkey ReferencesThe Use of Video Imaging Techniques to Study Ultrafiltration and Blood Flow in the Normal and Diseased Kidney I. Background II. Documentation of Filtration by Isolated Glomeruli III. Studies of Isolated Renal Microvessels IV Observations of Glomeruli during In Situ Perfusion V Studies of Blood-Perfused Juxtamedullary Nephrons VI. Documentation of Medullary Blood Flow VII. Prospects for the Future ReferencesChemically Induced Renal Epithelial Neoplasia in Experimental Animals I. Introduction II. Renal Tubule Epithelial Cell Neoplasia ReferencesIndex