Introduction to Clinical Oncology

9780121978020 Cancer and Chemotherapy, Volume II: Introduction to Clinical Oncology provides the basic framework for understanding antineoplastic drugs. The use of chemotherapeutics in the treatment of the most common human malignancies, including leukemias and lymphomas, is discussed. Solid tumors such as those affecting the breast and lung, head and neck, brain and spinal cord are also considered. Comprised of 17 chapters, this volume begins with an overview of leukemias and lymphomas, including their incidence, pathology, and clinical features. The discussion then turns to solid tumors such as breast and lung carcinoma; head and neck cancers; cancer of the brain and spinal cord; gastrointestinal, genitourinary, and gynecological cancers; and malignant melanoma. The next section is devoted to nutritional and infectious disease aspects of cancer and examines infections that arise in the cancer patient, particularly pneumonia and septicemia. The diagnosis of and therapy for these infections are outlined, along with granulocyte transfusion and prophylaxis of infection. The final chapter deals with nutrition in cancer patients and describes the link between cancer and malnutrition as well as the mechanisms of cancer-associated malnutrition. The advantages and methods of nutritional support for cancer patients are also highlighted. This book should be a valuable resource for oncologists.

List of ContributorsGeneral PrefacePreface to Volume IIPart I Leukemias and Lymphomas 1 The Acute Leukemias I. Introduction II. Incidence III. Classification IV. Predisposing Factors V. Presenting Features VI. Differential Diagnosis VII. Laboratory Features VIII. General Therapeutic Considerations IX. General Clinical Considerations X. Prognostic Factors XI. Conclusions References 2 Hairy Cell Leukemia I. Definition II. Incidence with Age and Sex Ratio III. Pathology IV. Pathogenesis V. Clinical Features VI. Laboratory Features VII. Treatment VIII. Course of Disease IX. Summary References 3 Chronic Lymphocytic Leukemia I. Definition II. Epidemiology III. Etiologic Features IV. Pathologic Observations V. Pathogenesis VI. Clinical Features VII. Laboratory Features VIII. Differential Diagnosis IX. Treatment X. Prognostic Factors XI. Course of Disease References 4 Chronic Myelocytic Leukemia I. Special Characteristics II. Clinical Features III. Clinical Course IV. Summary and Conclusions References 5 The Lymphomas I. Introduction II. Hodgkin's Disease III. Non-Hodgkin's Lymphomas IV. Conclusion ReferencesPart II Solid Tumors 6 Carcinoma of the Breast I. Introduction II. Incidence and Causative Factors III. Pathology IV. Clinical Presentation V. Prognostic Features VI. Clinical Course of Metastatic Breast Cancer VII. Surgical Therapy VIII. Radiation Therapy IX. Hormonal Therapy X. Chemotherapy XI. Discussion References 7 Clinical Presentations of Gastrointestinal Cancer I. Large-Bowel Carcinoma II. Carcinoma of the Pancreas III. Carcinoma of the Stomach References 8 Cancers of the Head and Neck I. Introduction II. Incidence III. Etiology IV. Histopathology and Spread V. Clinical Manifestations VI. Diagnosis VII. Clinical Staging VIII. Management IX. Conclusions References 9 Carcinoma of the Lung I. Introduction II. Classification III. Evaluation of Lung Cancer IV. Management of Non-Small-Cell Anaplastic Cancer V. Management of Metastatic Non-Small-Cell Anaplastic Lung Cancer VI. Evaluation and Management of Small-Cell Anaplastic Carcinoma VII. Conclusion References 10 Clinical Characteristics of Cancer in the Brain I. Introduction II. Tumors of the Brain III. Meningeal Carcinomatosis IV. Tumors of the Spinal Cord References 11 Genitourinary Cancer I. Introduction II. Renal Carcinoma III. Carcinoma of the Renal Pelvis IV. Carcinoma of the Ureter V. Female Urethral Carcinoma VI. Male Urethral Carcinoma VII. Penile Carcinoma VIII. Testicular Tumors IX. Bladder Cancer X. Prostate Cancer References 12 Gynecological Cancers I. Introduction II. Ovarian Cancer III. Cancer of the Cervix IV. Endometrial Carcinoma References 13 Malignant Melanoma I. Introduction II. Epidemiology III. Pathology IV. Clinical Findings V. Diagnosis VI. Prognosis VII. Treatment VIII. Conclusion References 14 The Sarcomas I. Introduction II. Diagnosis III. Soft Tissue Sarcomas IV. Sarcomas of Bone V.