Microbiota Brain Axis

Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.- Reviews the many approaches to manipulating the microbiota in animal studies - including the use of germ-free animals, antibiotics and diet - and covers the strengths and limitations of each- Outlines available microbiota research tools, such as 16S sequencing and shot-gun metagenomics- Provides a comprehensive guide to analyzing microbiota-related data and the many choices for bioinformatics

Dr. Jane Foster, Ph.D., is a Professor in the Department of Psychiatry, at the Center for Depression Research and Clinical Care at UT Southwestern Medical Center in Dallas, Texas. In the past 20 years, Dr. Foster has developed an internationally recognized translational research program that uses a 'bench to bedside' and back again approach to studying microbiota - brain and immune - brain systems. As one of the early proponents of the role of gut - brain axis in mental health, her lab produced important data demonstrating a role for the microbiome in brain development and behavior in animal studies and recently has extended this work to study the complex neurobiological underpinnings of microbiota - brain and neuroimmune systems in psychiatric illness in clinical populations. Her multidisciplinary expertise includes behavioral neuroscience, molecular biology, immunology, neuroimaging, microbiome, and bioinformatics in both preclinical and clinical research domains. Dr. Foster's research program has developed high-quality analytical pipelines for biological data and novel analytical tools for integrating data across modalities.Prof. Gerard Clarke, Ph.D., is a Professor of Neurobehavioral Science inthe Department of Psychiatry and Neurobehavioral Science and a PrincipalInvestigator in APC Microbiome Ireland at University College Cork. Hisresearch program includes a focus on translational biomarkers of stress-relatedneuropsychiatric disorders, the impact of the gut microbiome onbrain and behavior across the life span, and microbial regulation of tryptophanmetabolism. Key achievements of his lab in the generation ofknowledge around the microbiota - gut - brain axis include the demonstrationthat the gut microbiome regulates the hippocampal serotonergicsystem in a sex-dependent manner, findings that paved the way fornumerous lines of inquiry on the effects of the gut microbiome on neurodevelopment,brain function, and behavior. He is regularly included inClarivate Analytics Highly Cited Researchers list, placing him among theworld's top one percent of researchers by citation. His current approach isbased on advancing frontier knowledge in microbiome research to yieldpotential new therapeutic targets for the effective treatment of the centralnervous system and gastrointestinal disorders.

1. The gut-brain axis2. What is a healthy microbiome?3. Gene-environment factors influence microbiota composition, diversity, and function4. Microbiota to brain communication5. Microbiota influence behaviour - work in animal models6. Microbiota influence brain systems - work in animal models7. Microbiota in neurodevelopmental disorders8. Microbiota in psychiatry9. Microbiota-brain interactions in aging and neurodegeneration10. Pharmacological treatments and the microbiome - Antibiotics and nonantibiotic drugs11. Microbial-related treatments12. Microbiota-related biomarkers for precision medicine and drug discovery