Heavy Particle Radiotherapy

Heavy Particle Radiotherapy covers the significant advances in the application of radiotherapy to cancer treatment. This book is composed of eight chapters that focus on the performance of several heavy particles. The introductory chapters describe the radiobiological phenomena of interest in radiotherapy and their modifications with increasing linear energy transfer. The remaining chapters discuss the physical aspects, cellular effects, and radiotherapy potential of heavy particles, including neutrons, protons, helium and heavy ions, and negative pions.

ForewordAcknowledgmentsIntroductionChapter 1 Radiobiological Phenomena I Introduction II Oxygen Effect III Cell-Cycle Sensitivity IV Recovery from Damage ReferencesChapter 2 Biological Effects of High-LET Radiations I Introduction II Interaction of Heavy Particles with Tissue III Sources of High-LET Radiations IV Cell Survival for High-LET Radiations V OER vs LET VI RBE and OER for High- and Low-LET Radiations VII Cell-Cycle Sensitivity Variation vs LET VIII Recovery from Sublethal Injury Inflicted by Radiations of Different LET IX Recovery from Potentially Lethal Damage Inflicted by High-LET Radiations X Hypoxic Cell Sensitizers and High-LET Radiations ReferencesChapter 3 Neutrons I Introduction II Early Experiences with Fast Neutrons and Their Implications for Future Use of High-LET Radiations in Therapy III Fast Neutron Sources IV Physical Aspects of Fast Neutrons V Effects of Neutrons on Cultured Cells VI Effects of Neutrons on Normal Tissues VII Effects of Neutrons on Tumors VIII Neutron Dosimetry and Radiobiology Intercomparisons IX Current Neutron Radiotherapy X Neutron Capture Therapy XI Radiotherapy with Californium-252 ReferencesChapter 4 Protons I Introduction II Physical Aspects III Biological Effects IV Clinical Experiences with Protons ReferencesChapter 5 Helium Ions I Introduction II Physical Aspects III Biological Effects IV Clinical Experiences with Helium Ions ReferencesChapter 6 Heavy Ions I Introduction II Physical Aspects III Heavy Ion Radiobiology IV Clinical Studies with Heavy Ions ReferencesChapter 7 Negative Pions I Introduction II Physical Aspects III Biological Effects of Negative Pions IV Clinical Results ReferencesChapter 8 Comparison of Heavy Particles I Introduction II A Radiobiological Comparison of Heavy Particles ReferencesAppendix Radiobiological Techniques I Introduction II Mammalian Cell Survival Curves (In Vitro) III Mammalian Cell Survival Curves (In Vivo) IV Solid Tumors V Skin Reactions VI Late Reactions in Normal Tissues ReferencesIndex