Malaria

Malaria: Volume 3, Immunology and Immunization is a collection of papers dealing with malaria parasites, the methods for measuring the immunological response to plasmodia, and the vertebrates host's immune response to plasmodia. Some papers discuss immunization against sporozoites, against the exoerythrocytic stages of malaria parasites, against asexual blood-inhabiting stages of plasmodia, as well as gamete immunization in malaria. One paper describes various separation methods to isolate malaria parasites and their constituents. Another paper discusses in detail the theory and practice of methods used in measuring antibody responses which occur during plasmodial infections, including the antibody response against sporozoites, exoerythrocytic forms, and in the different blood stages. Another paper explains the vertebrate host's immune response to plasmodial infection as a homeostatic physiological response changing along with the progression of the disease. The changes in the dynamic cellular cascade are different as the disease progresses causing death, than when these lead to recovery. Another paper enumerates the parameters which determine malarial infectiousness from one individual to another such as the time of onset, duration, intensity of the blood infections, as well as the maturity, longevity, and rate of production of gametocytes. Pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in malarial research will find the collection very useful.

-List of ContributorsPrefaceContents of Volumes 1 and 2Contents of Babesiosis1 The Isolation of Malaria Parasites and Their Constituents I. Introduction II. Isolation of Plasmodia and Their Constituents III. Conclusions References2 Methods for Measuring the Immunological Response to Plasmodia I. Introduction II. The Antibody Response against Sporozoites III. The Antibody Response against Exoerythrocytic Forms IV. The Antibody Response to Blood Stages Reference3 The Vertebrate Host's Immune Response to Plasmodia I. Introduction II. The Immune Response against Plasmodia III. Summary and Hypothesis: Probable Mechanisms of Immunity to Plasmodia References4 Immunization against Sporozoites I. Introduction II. Immunization of Rodents against Sporozoite-Induced Malaria III. Immunization of Simian Hosts against Sporozoite-Induced Malaria IV. Immunization of Humans against Sporozoite-Induced Malaria V. Conclusions VI. Perspectives References5 Immunization against Exoerythrocytic Stages of Malaria Parasites I. Introduction II. Immune Responsiveness to Exoerythrocytic Stages III. Discussion References6 Immunization against Asexual Blood-Inhabiting Stages of Plasmodia I. Introduction II. Immunization against Bird Malaria Parasites III. Immunization against Rodent Malaria Parasites IV. Immunization against Simian Malaria Parasites V. Immunization against Human Malaria Parasites VI. Summary and Conclusion References7 Infectiousness and Gamete Immunization in Malaria I. Introduction II. Avian Malaria (Plasmodium gallinaceum) III. Rodent Malaria(Plasmodium yoelii) IV. Simian Malaria V. Human Malaria VI. Conclusions ReferencesAppendix 1 Prospects for Development of Vaccines against Plasmodium falciparum Infection I. Introduction II. Experimental Immunization against Plasmodium falciparum Blood Stages III. Immunization of Humans against Sporozoite-Induced Malaria IV. Prerequisites for Vaccines for Human Use V. Conclusions ReferencesAppendix 2 The Role of Vaccination in the Strategy of Malaria Control Text ReferencesAppendix 3 Prospects for Malaria Blood Stage Vaccine Text ReferencesAppendix 4 Manufacturing Aspects of Antiplasmodial Vaccine Production Text ReferencesAppendix 5 The Agency of International Development Program for Malaria Vaccine Research and Development TextAppendix 6 The Great Neglected Diseases of Mankind Text ReferencesIndex