Managing Treatment-Resistant Depression

Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD.- Defines Treatment-Resistant Depression and Staging Treatment Intensity
- Includes Treatment-Resistant Depression options for children, adolescents, geriatrics, during pregnancy, and during post-partum and menopause transitions
- Discusses the use of Ketamine and Esketamine for treatment-resistant depression

1. Defining treatment-resistant depression, difficult-to-treat depression, and staging treatment intensity2. Clinical and epidemiological predictors of treatment-resistant depression3. The economic burden of treatment-resistant depression: Cost-of-illness perspective4. The neurobiology of treatmentresistant depression5. Modeling treatment-resistant depression in the preclinical setting6. Treatment algorithms for treatment-resistant depression7. Tools to aid precision treatments to prevent or manage treatmentresistant depression (TRD): Pharmacogenomics, machine learning, and artificial intelligence8. Tricyclic antidepressants for treatment-resistant depression9. Monoamine oxidase inhibitors for treatment-resistant depression10. Switching antidepressants in patients with treatment-resistant depression11. Adjunctive strategies for treatment-resistant depression12. Combining antidepressants to address treatment-resistant depression13. Ketamine/esketamine for treatment-resistant depression14. Psychedelic agents for treatmentresistant depression15. Inflammation and treatment resistance: Mechanisms and treatment implications16. Opioid agents for treatmentresistant depression17. Transcranial magnetic stimulation for treatment-resistant depression18. tDCS for treatment-resistant depression19. ECT for treatment-resistant depression20. MST for treatment-resistant depression21. VNS for treatment-resistant depression22. Deep brain stimulation for treatment-resistant depression23. Other neurosurgical interventions for treatment-resistant depression24. Treatment-resistant psychotic depression25. Evidence-based psychotherapy for treatment-resistant depression26. Treatment-resistant bipolar depression27. Treatment-resistant depression in child and adolescents28. Treatment-resistant depression in geriatrics29. Identification and management of anxious depression in patients with treatment-resistant depression30. Managing treatment-resistant depression with comorbid personality disorders31. Managing treatment-resistant depression with comorbid substance use disorders32. Managing treatment-resistant depression in the setting of chronic pain33. Inhaled gases for treatmentresistant major depression34. Drugs under investigation for treatment-resistant depression35. Chronotherapeutics for treatmentresistant depression36. Managing treatment resistant depression in primary care settings37. Treatment-resistant depression in pregnancy, the postpartum period, and transition to menopause38. Lifestyle interventions for treatment-resistant depression39. Managing the risk of suicide in people with treatment-resistant depression40. Maintaining motivation and preserving the therapeutic alliance as tools to overcome treatmentresistant depression