Immunology of the Liver

Immunology of the Liver contains the proceedings of an International Meeting held at King's College Hospital Medical School in London on July 6-7, 1970. The meeting provided a forum for discussing progress made in understanding the immunology of the liver and tackled topics ranging from the pathology of chronic hepatitis to the occurrence and distribution of tissue antibodies in liver diseases. Cell-mediated responses and manifestations of immunological damage are also explored. Comprised of 33 chapters, this book begins with an introduction to the clinical, morphological, and virological aspects of liver disease. In particular, the clinical spectrum of autoimmune liver disease is considered, along with the pathology of chronic hepatitis. Morphological and immunological studies on chronic aggressive hepatitis and primary biliary cirrhosis are presented. Subsequent chapters focus on antibodies related to mitochondria; leukocyte migration in active chronic hepatitis and primary biliary cirrhosis; immunologic observations and electron microscopy of halothane-induced hepatic injury; and humoral and delayed hypersensitivity in chronic hepatitis. The final sections deal with results of immunosuppressive therapy and the immunology of liver transplantation. This monograph will be of interest to immunologists, pathologists, physiologists, clinicians, and research workers in the field of medicine.

Editors' ForewordList of ParticipantsOpening AddressPart I Clinical, Morphological and Virological Aspects Clinical Spectrum of Auto-Immune Liver Disease The Pathology of Chronic Hepatitis Morphological and Immunological Studies on Chronic Aggressive Hepatitis and Primary Biliary Cirrhosis Australia Antigen in the Chilean Population Electron Microscopic Observations on SH Antigen Using Positive Staining Round Table DiscussionPart II The Occurrence and Role of Antibodies Occurrence and Distribution of Tissue Antibodies in Liver Diseases Antibodies Related to Mitochondria: Multiple Specificities and Clinical Associations Antibodies to Bile Canaliculi in Patients with Chronic Active Liver Disease Serum Total Haemolytic Complement in Liver Disease Properties of Antibodies Reacting with Homologous and Heterologous Liver Mitochondrial Fractions Round Table DiscussionPart III Cell Mediated Responses and Manifestations of Immunological Damage Theoretical Basis of the Leucocyte Migration Test Leucocyte Migration in Active Chronic Hepatitis and Primary Biliary Cirrhosis The Anergic State and Other Immunological Changes in Primary Biliary Cirrhosis Induction and Transfer of Auto-Immune Periductular Fibrosis in Inbred Rat Strains - with Evidence for Predominantly Cell-Mediated Pathogenesis Characterization and Isolation of Liver Specific Proteins in Different Species; their Importance for Experimental Models and in Diagnosis of Chronic Hepatitis Immunologic Observations and Electron Microscopy of Halothane-Induced Hepatic Injury Studies on Multi-System Involvement in Active Chronic Hepatitis and Primary Biliary Cirrhosis Some Aspects of Humoral and Delayed Hypersensitivity in Chronic Hepatitis Round Table DiscussionPart IV Results of Immunosuppressive Therapy Problems of Multi-Centre Trials, Illustrated by the Copenhagen Trial of Steroid Therapy in Cirrhosis Prednisolone Therapy in Active Chronic Hepatitis A Long-Term Study of Immunosuppressive Therapy in Active Chronic Hepatitis Treatment of Chronic Hepatitis with Azathioprine and Prednisone Combined A Controlled Trial of Prednisone and Azathioprine in Active Chronic Hepatitis Experience with Azathioprine in Primary Biliary Cirrhosis Round Table DiscussionPart V Some Aspects of the Immunology of Liver Transplantation Results with Relation to Tissue Typing and Recurrence of Primary Hepatoma The Leucocyte Migration Test in Assessment of Rejection Assay of Serum Immunosuppressive Activity After Liver Transplantation Immunological Aspects of Organ Grafting in the Pig