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Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells. The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their activity. The text is further divided into five major sections according to the sequence of the workshop sessions. A separate chapter from the sections has been included at the beginning of the book. The introductory chapter clarifies some points in the subject area of NK cells, particularly its definition. The heterogeneity of NK cells is also discussed in this chapter. Then, the book presents the major topics, including the purification and characterization of NK cells and NK target structures and recognition sites. The mechanisms of postrecognition interactions between NK cells and targets; regulation of NK activity and NK cells; and cultured cells with NK-like activity are also discussed. This book will serve as a helpful guide to students and professionals (scientists, researchers, and professors) in the fields of immunology, biology, microbiology, biochemistry, among others.
Contributors PrefaceI Purification and Characterization of NK Cells Purification and Characterization of NK Cells Surface Phenotype and Functions of Human Natural Killer Cells Characteristics of Mouse NK Cells and Their Precursors Enrichment Methodology for Murine NK ActivityII Characterization of NK Target Structures and Recognition Sites on NK Cells Molecular Characterization of NK Target Antigens and Target Recognition Sites on NK Cells Analysis of NK Target Structures.
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