Metabolic Bone Disease

Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in calcium and phosphate metabolism; as well as the role of alkaline phosphatase in metabolic bone disorders. The text also describes the diagnostic value of bone biopsies; the etiology, clinical aspects, therapy, and the main syndromes of vitamin D deficiency, rickets, and osteomalacia; and the pathogenesis and therapy of osteoporosis. The pathogenesis and treatment of nephrolothiasis are also encompassed. Orthopedic doctors, physicians, endocrinologists, and people involved in the research of metabolic bone diseases will find the book invaluable.

List of ContributorsPrefaceContents of Other Volumes1 Bone Metabolism and Calcium Regulation I. Introduction II. General Problem of Calcium Regulation III. General Description of Skeletal Structure and Function IV. Distribution and Transport of Calcium and Phosphate V. Regulation of Bone Formation VI. Regulation of Bone Resorption VII. Cellular Calcium Regulation General References References2 Kidney Function in Calcium and Phosphate Metabolism I. Renal Phosphate Transport II. Renal Calcium Transport III. Renal Physiology and the Effects of Parathyroid Hormone and Calcitonin on Electrolyte Homeostasis References3 Alkaline Phosphatase and Metabolic Bone Disorders I. Historical II. Alkaline Phosphatase and Calcification III. Localization and Purification of Skeletal Alkaline Phosphatase IV. Tissue Sources of Circulating Alkaline Phosphatases in Normal and Abnormal Subjects V. Methods of Assay: Normal Values VI. The Diagnostic Value of Serum Alkaline Phosphatase Determinations in Skeletal Disorders VII. Alkaline Phosphatase Elevations in Extraskeletal Disorders VIII. "Stop-Go" Decisions Based on Serum Alkaline Phosphatase IX. Acid Phosphatase X. Conclusions References4 The Diagnostic Value of Bone Biopsies I. Introduction II. Growth III. Ossification IV. Remodeling and Turnover V. Resorption VI. Reversal Lines VII. Formation VIII. Technical Considerations IX. Skeletal Variability and the Value of Bone Biopsy X. Quantitative Values in Biopsy Diagnosis XI. Bone Changes in Metabolic Bone Disease XII. Appendix References5 Vitamin D, Rickets, and Osteomalacia I. Introduction II. Vitamin D and Its Metabolism III. Etiology, Nomenclature, and Clinical Aspects IV. Radiological and Laboratory Diagnosis V. Differential Diagnosis VI. Therapy VII. Main Diseases and Syndromes Causing Rickets or Osteomalacia VIII. Conclusion References6 Osteoporosis: Pathogenesis and Therapy I. Definition II. Physiological Osteopenia III. Diagnostic Aids IV. Classification References7 Nephrolithiasis I. Introduction II. Types of Stones Found in the Urinary Tract III. Stone Formation and Growth IV. Pathogenesis of Recurrent Stone Disease V. Specific Disease of Bone Associated with Nephrolithiasis VI. Treatment of Renal Stone Disease ReferencesIndex