Modern Inference Based on Health-Related Markers

Modern Inference Based on Health Related Markers: Biomarkers and Statistical Decision Making provides a compendium of biomarkers based methodologies for respective health related fields and health related marker-specific biostatistical techniques. These methodologies may be applied to various problems encountered in medical and epidemiological studies. This book introduces correct and efficient testing mechanisms including procedures based on bootstrap and permutation methods with the aim of making these techniques assessable to practical researchers. In the biostatistical aspect, it describes how to correctly state testing problems, but it also includes novel results, which have appeared in current statistical publications. The book discusses also modern applied statistical developments that consider data-driven techniques, including empirical likelihood methods and other simple and efficient methods to derive statistical tools for use in health related studies. The title is a valuable source for biostaticians, practitioners, theoretical and applied investigators, and several members of the biomedical field who are interested in learning more about efficient evidence-based inference incorporating several forms of markers measurements.
- Combines modern epidemiological and public health discoveries with cutting-edge biostatistical tools, including relevant software codes, offering one full package to meet the demand of practical investigators - Includes the emerging topics from real health fields in order to display recent advances and trends in Biomarkers and associated Decision Making areas - Written by researchers who are leaders of Epidemiological and Biostatistical fields, presenting up-to-date investigations related to the measuring health issues, emerging fields of biomarkers, designing health studies and their implementations, clinical trials and their practices and applications, different aspects of genetic markers

Part 1: Measure of Health via Biomarkers1. Emergence of Modern Biomarkers based Developments in Health Studies2. Cancer studies in light of advances in Biomarkers developments3. Is Body Fat the Best Measure of Health?Part 2: Designing health investigations and their implementations4. Topic: Pooling5. Topic: Reproductive/perinatal epidemiology, epidemiologic methodsPart 3: Special topics in Modern Epidemiology6. Biomarkers use in Modified Risk Tobacco Products7. Collider stratification bias due to censoring in prospective cohort studies8. Roles of Biomarkers in breast cancer research and treatmentPart 4: Biostatistical Toolkits to evaluate Health related Markers9. Topics: Biomarkers data analysis and decision making mechanisms based on data subject to different sorts of measuring errors; Parametric and nonparametric procedures for biomarkers evaluationsPart 5: Clinical Trials: practices and applications10. Phase 111. Phase 2Part 6: Genetic Markers12. Biomarkers13. Molecular Biomarkers14. Cancer Biomarkers15. Cancer epidemiology and biomarkers16. Immuno oncology biomarkers17. Biomarkers for the prognosis of cancer and prediction of treatment18. Use of biomarkers for developing drug targets19. Biomarkers and diseases20. Biomarkers and Next-Generation Sequencing21. Biomarkers and Radiology22. Advances of Biomarker statistical evaluations23. Clinical Applications of Biomarkers