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Molecular Diseases, Volume 56 presents the interrelated problems of synthesis, assembly, and breakdown of the various organelles of the cell for which powerful methods have been developed. This book discusses the processing of virus-coded proteins. Organized into nine chapters, this volume begins with an overview of the primary causes that can account for the hereditary defects of enzyme activity. This text then examines the basic methodological aspects of the assessment of protein turnover in a complex intact mammalian organism. Other chapters consider the method of desialylation of erythrocytes and their in vivo and in vitro behavior after this treatment. This book discusses as well the interrelationship between the peroxidatic enzymes and superoxide dismutase in the red cell. The final chapter deals with the use of liposomes as enzyme carriers in the treatment of lysosomal storage diseases. This book is a valuable resource for biological and medical students in various fields.
PrefaceMolecular Basis of the Hereditary Defects of Enzyme ActivityHaemolytic Anaemia in Pyruvate Kinase Deficiency: Possibilities of TherapyMembrane Desialylation and Elimination of ErythrocytesReactive Oxygen Metabolites and HaemolysisRed Blood Cell Membrane Defects in ß-Thalassemia and the Therapeutic Role of a-Tocopherol (Vitamin E)Haemoglobin Precipitation and Red Cell HaemolysisReversion of HGPRT Deficiency of Skin Fibroblasts from Lesch-Nyhan PatientsSubstitution Therapy in Lysosomal Storage DiseasesIntroduction of Enzymes into Liver Cells by Means of LiposomesAuthor IndexSubject Index
