Monoclonal Antibodies against Bacteria

Monoclonal Antibodies against Bacteria, Volume I explores the generation, characterization, and utilization of monoclonal antibodies against bacteria and on other monoclonal products relevant to antibacterial immune responses. Organized into 12 chapters, this book begins with a discussion on monoclonal antibodies against bacteria, encompassing its scope, research, and directions. It shows that the coordinated use of antisera and panels of monoclonal antibodies is proving useful for classification as a diagnostic tool with prognostic implications in the case of pathogens, or as a preliminary step in taxonomy. Also, monoclonal antibodies hold great potential as instruments in working with bacteria for industrial or biotechnological purposes, including genetic engineering. This book also elucidates the use of monoclonal antibodies of predefined molecular specificity for tracing molecular ""signatures"" left by a given strain in other microorganisms, subcellular structures, and materials from ecologic niches. The possibility of antibacterial and antitoxin therapies with monoclonal antibodies is also addressed. This treatise will be a valuable reference work to anyone working with monoclonal antibodies or getting ready to prepare them against the strain(s) (or bacterial structures) of his/her interest.

ContributorsPrefaceIntroduction: Monoclonal Antibodies against Bacteria for Medicine, Dentistry, Veterinary Sciences, Biotechnology, and Industry-An OverviewContents of Volume II1 Monoclonal Antibodies against Gonococcal Pili: Uses in the Analysis of Gonococcal Immunochemistry and Virulence I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References2 Monoclonal Antibodies against Group B Streptococcus I. Introduction II. Background III. Methods and Results IV. Conclusions V. Summary References3 Studies with Monoclonal Antibodies to Mycobacteria I. Introduction II. Results and Discussion III. Conclusions and Prospects for the Future IV. Summary References4 Monoclonal Antibodies to Characterize the Antigenic Heterogeneity of Bacteroides intermedius I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References5 Monoclonal Antibodies against Legionella pneumophila Serogroup 1 Antigens: Characterization and Their Potential Applications I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References6 Monoclonal Antibodies Specific for the O-Antigen of Shigella flexneri and Shigella sonnei: Immunochemical Characterization and Clinical Usefulness I. Introduction II. Background III. Results and Discussion IV. Conclusions and Prospects for the Future V. Summary References7 Monoclonal Antibodies against Group- and Type-Specific Antigens of Vibrio cholerae O:1 I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References8 Monoclonal Antibodies against Tetanus Toxin and Tetanus Toxoid I. Introduction II. Background III. Methods for Generation of Monoclonal Antibodies IV. Results and Discussion V. Prospects for the Future VI. Summary References9 Human Monoclonal Antibodies for Prophylaxis and Therapy of Bacterial Infections I. Introduction II. Background III. Results and Discussion IV. Conclusions and Future Prospects V. Summary References10 Monoclonal T Cells and T-Cell Hybridomas with Antibacterial Activity I. Introduction II. Background III. Results and Discussion IV. Conclusions and Prospects for the Future V. Summary References11 A Preview of the Uses of Monoclonal Antibodies against Methanogens in Fermentation Biotechnology: Significance for Public Health I. Introduction II. Background III. Results and Discussion IV. Conclusions V. Prospects for the Future VI. Summary References12 An International Hybridoma Data Bank: Aims, Structure, Function I. Introduction II. Background of Sponsoring Organizations III. Operations Framework IV. System Design V. Funding and Support VI. Prospects for the Future VII. Conclusions VIII. Summary ReferencesIndex