Myocardial Infarction And Cardiac Death

Medicinal Chemistry, Volume 18: Myocardial Infarction and Cardiac Death focuses on the prevention and treatment of myocardial infarction. This book explores the synthesis and biological evaluations of hypolipidemic agents. Organized into seven chapters, this volume starts with an overview of the anatomical and functional characteristics of the blood vessels, which is important in understanding the effect on the microcirculation of alterations in blood flow as would occur in myocardial infarction. This text then explores the two serious consequences that result from occlusion of the coronary arteries and the resultant myocardial infarction, namely, the failure of the heart as pump and the development of life-threatening arrhythmias. Other chapters review the medical treatment for primary and secondary prevention of myocardial infarction and sudden death. The final chapter deals with the interventions in the prevention of myocardial infarction, including drug therapy, surgical procedures, and lifestyle modifications. This book is a valuable resource for cardiologists and other health professionals.

In MemoriamContributorsPreface1. Role of the Microvasculature in Myocardial Infarction I. The Microvasculature of the Myocardium II. Microcirculation in Myocardial Infarction References2. Animal Studies in Artificially Induced Myocardial Infarction I. Introduction II. Methods of Producing Coronary Artery Occlusion III. Ventricular Arrhythmia Associated with Myocardial Infarction IV. Ischemia and Infarction V. Summary References3. Pharmacologic Approaches to the Prevention of Myocardial Infarction and Sudden Death I. Introduction II. ß-Adrenoceptor Blocking Drugs III. Lipid-Lowering Agents IV. Vitamin - V. Anticoagulation Therapy (Heparin and Sodium Warfarin) VI. Anticoagulation (Antiplatelet Agents) VII. Coronary Artery Surgery VIII. Summary References4. Pharmacology of Antiplatelet Agents and Their Role in Coronary Disease I. Summary of Clinical Trials of Antiplatelet Agents II. Thrombus Formation in Arteries III. Thromboembolism and Clinical Complications of Coronary Disease IV. Effects of Substances Produced by Injured Vessel Walls V. The Role of Platelets in the Initiation of Coronary Artery Disease VI. Tests of the Effects of Drugs on Platelet Reactions VII. Drugs That Inhibit Platelet Reactions References5. Platelets, Thrombosis, Atherosclerosis in Myocardial Infarction: Interactions and Relationships I. Introduction II. Platelets and Thrombosis in Atherogenesis III. Thrombosis in Progression of Atherosclerosis IV. Thrombotic Complications of Atherosclerosis V. Coronary Occlusion, Thromboembolism, and Cardiac Death VI. Summary References6. Clinical Pathogenesis and Physiological Processes Involved in Myocardial Infarction and Sudden Cardiac Death I. Introduction II. The Clinical Setting of Sudden Death III. Pathology of Sudden Death IV. The Clinical Precursors of Sudden Death V. Mechanism of Sudden Death VI. Metabolic and Electrophysiologic Mechanisms VII. Central and Autonomic Nervous Systems and Sudden Death References7. Considerations in the Design, Execution, and Interpretation of Clinical Trials in Cardiac Mortality I. Introduction II. Methodological Standards in Clinical Trials III. Considerations for the Design of Future Studies IV. Multiple Analysis V. Summary ReferencesIndex