Oxidative Eustress in Exercise Physiology

Oxidative Eustress in Exercise Physiology unravels key physiological responses and adaptations to different redox-regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease. While the mechanistic details are still unclear, key intracellular redox indices seem to be dysregulated with age. Consequently, beneficial molecular responses to acute endurance exercise decline in older individuals. Recent research suggests that manipulating mitochondrial redox homeostasis by supplementing with the mitochondria-targeted coenzyme Q10 for six weeks markedly improves physical function in older adults; i.e. it may be possible to maximise the benefits of exercise by manipulating the redox environment. The research described in this book suggests that significant translational potential exists with respect to cardiovascular disease, neurodegeneration and cancer. An international team of researchers documents the importance of redox biology in health and disease, especially when exercise is a clinically useful tool for the treatment of many diseases and conditions. Features - Defines essential redox biology reactions and concepts in exercise physiology - Assesses key redox parameters in an in vivo human exercise context - Identifies the challenges, opportunities and boundaries of current knowledge - Includes a critique of the underlying mechanisms - Summarises examples of translationally important research relating to disease states Related Titles Draper, N. & H. Marshall. Exercise Physiology for Health and Sports Performance (ISBN 978-0-2737-7872-1) Wackerhage, H., ed. Molecular Exercise Physiology: An Introduction (ISBN 978-0-4156-0788-9)

Gareth Davison is Professor of Exercise Biochemistry and Physiology and Director of Research at the Sport and Exercise Sciences Research Institute at Ulster University in the UK. He holds a BA, MSc, and an MSt in Genomic Medicine from the University of Cambridge and was awarded his PhD in Biochemistry and Physiology in 2002. Professor Davison is a Fellow of the American College of Sports Medicine, and currently serves on several editorial boards, holding Editor roles with the Journal of Sports Sciences, Frontiers in Physiology (Redox Physiology Section) and Antioxidants. His research interests are aligned to exercise, DNA damage and antioxidant function. Recently, his laboratory has focused on bridging the gap between intracellular redox metabolism and DNA methylation in health and disease. James Cobley is a Senior Lecturer in Free Radicals at the University of the Highlands and Islands (Inverness, UK). His doctoral work, completed in 2013, focused on the redox regulation of molecular exercise adaptations in young and old human skeletal muscle. Since then, Dr Cobley has focused on developing methods to measure protein thiol redox state; which has resulted in the development of two new methods: ALISA and RedoxiFluor. Dr Cobley intends, in collaboration with others, to use both technologies to determine if and how protein thiol defined redox signalling regulates exercise adaptations and responses.

1. Introduction to Oxidative (Eu)stress in Exercise Physiology.Gareth W. Davison and James N. Cobley. 2. Measuring Oxidative Damage and Redox Signalling: Principles, Challenges, and Opportunities. James N. Cobley and Gareth W. Davison. 3. Exercise Redox Signalling: From ROS Sources to Widespread Health Adaptation. Ruy A. Louzada, Jessica Bouviere, Rodrigo S. Fortunato, Denise P. Carvalho. 4. Oxygen transport: a redox O2dyssey. Chatzinikolaou PN, Margaritelis NV, Chatzinikolaou AN, Paschalis V, Theodorou AA, Vrabas IS, Kyparos A, Nikolaidis MG. 5. Mitochondrial redox regulation in adaptation to exercise. Christopher P. Hedges and Troy L. Merry. 6. Basal Redox Status Influences the Adaptive Redox Response to Regular Exercise. Ethan L. Ostrom and Tinna Traustadóttir. 7. Time to 'couple' redox biology with exercise immunology. Alex J Wadley and Steven J Coles. 8. Exercise and RNA oxidation. Emil List Larsen, Kristian Karstoft, Henrik Enghusen Poulsen. 9. Exercise and DNA Damage: Considerations for the Nuclear and Mitochondrial Genome. Josh Williamson and Gareth W. Davison. 10. Nutritional Antioxidants for Sports Performance. Jamie N. Pugh and Graeme L. Close. 11. Antioxidant supplements and exercise adaptations. Shaun A. Mason, Lewan Parker, Adam J. Trewin, Glenn D. Wadley. 12. Nitric oxide biochemistry and exercise performance in humans: influence of nitrate supplementation. Stephen J. Bailey and Andrew M. Jones. 13. (Poly)phenols in exercise performance and recovery - more than an antioxidant? Tom Clifford and Glyn Howatson. 14. Exercise: a strategy to target oxidative stress in cancer. Amélie Rébillard, Cindy Richard, Suzanne Dufresne. 15. Oxidative Stress and Exericse Tolerance in Cystic Fibrosis. Cassandra C. Derella, Adeola Sanni, Ryan A. Harris. 16. Ageing, Neurodegeneration and Alzheimer's Disease - The Underlying Role Of Oxidative Distress. Richard J Elsworthy and Sarah Aldred. 17. Exercise, Metabolism and Oxidative Stress in the Epigenetic Landscape. Gareth W. Davison and Colum P. Walsh.