Principles of Diabetes Mellitus

Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.

I. The main events in the history of diabetes mellitus.- 1. Normal glucose homeostasis.- 2. Endocrine pancreas: mechanisms of insulin secretion by the ?-cells; interactions among insulin, glucagon and somatostatin.- 3. Cellular mechanisms of insulin action.- 1. Diagnostic criteria and classification of diabetes.- 2. Epidemiology of diabetes and its burden in the world and in the United States.- 1. Diabetes genes. Human genome project and diabetes mellitus.- 2. Animal models of diabetes.- 1. Type 1 diabetes mellitus: epidemiology, genetics, pathogenesis and clinical manifestations.- 2. Type 2 diabetes mellitus: etiology, pathogenesis and clinical manifestations.- 3. Maturity-onset diabetes of the young: molecular genetics, clinical manifestations and therapy.- 4. Diabetes in pregnancy.- 5. Secondary causes of diabetes mellitus.- 6. Syndromes of extreme insulin resistance.- 1. Acute hyperglycemic syndromes: diabetic ketoacidosis and the hyperosmolar state.- 2. Hypoglycemia.- 3. Microvascular complications of diabetes mellitus.- 4. Diabetic retinopathy.- 5. Diabetic nephropathy.- 6. Diabetic neuropathy.- 7. Peripheral vascular disease in diabetes.- 8. The diabetic foot.- 9. Male sexual dysfunction in diabetes mellitus.- 10. Gastrointestinal manifestations of diabetes.- 11. Hyperlipidemia: pathogenesis and management in diabetes mellitus.- 12. Dermatological complications of diabetes mellitus; allergy to insulin and oral agents.- 1. Glycemic goals.- 2. Behavioral and educational approaches to diabetes self-management.- 3. Dietary therapy of diabetes mellitus.- 4. Exercise in the therapy of diabetes mellitus.- 5. Therapy of type 1 diabetes mellitus.- 6. Therapy of type 2 diabetes mellitus.- 7. Prevention of microvascular complications of diabetes.- 8. Psychological andpsychiatric issues in diabetes mellitus.- 1. Obesity - genetics, pathogenesis, therapy.- 2. Hypertension.- 3. Coronary artery disease and cardiomyopathy.- 4. Polycystic ovary syndrome.- 5. Insulin resistance and the Metabolic Syndrome.- IX. Diabetes prevention.- X. Resources for patients with diabetes.