Progress in Hodgkin's Disease

International Review of Experimental Pathology, Volume 33: Progress in Hodgkin's Disease summarizes the progress made in the diagnosis and understanding of the pathogenesis of Hodgkin's disease. The first half of this volume deals with diagnostic aspects, whereas the second half focuses on recent developments in the understanding of the pathogenesis of Hodgkin's disease. The book opens with a chapter on the differential diagnosis between Hodgkin's disease and non-Hodgkin's lymphomas, and provides guidelines on how to deal with the grey areas between these two groups of diseases. Separate chapters follow on the criteria for a prognostically relevant histological grading of the most common subtype of Hodgkin's disease; data on the nodular lymphocyte predominance subtype of Hodgkin's disease; and the various reagents used to define the immunophenotype of Reed-Sternberg cells. Subsequent chapters deal with potential mediators of lymphocyte agglutination to Reed-Sternberg cells; immunological alterations in Hodgkin's disease; molecular genetic studies into the pathogenesis of Hodgkin's disease; and results of studies on Hodgkin cell lines. This book provides data that go beyond those covered in textbooks in pathology and hematology and should be of interest to all pathologists and clinicians dealing with the diagnosis and management of Hodgkin's disease, as well as to lymphoma researchers.

ContributorsPrefaceDifferential Diagnosis between Hodgkin's Disease and Non-Hodgkin's Lymphoma I. Introduction II. Low Grade B Cell Lymphoma III. Pleomorphic ("Peripheral") T Cell Lymphomas IV. Large Cell Lymphoma and Anaplastic Large Cell Lymphoma V. Conclusions ReferencesDiagnosis and Grading of Nodular Sclerosing Hodgkin's Disease: A Study of 2190 Patients I. Introduction II. Patient Population III. Histological Criteria IV. The Clinical Relevance of Grading NS V. Discussion ReferencesLymphocyte-Predominance Hodgkin's Disease I. History II. Histology III. Cytology of L&H Type RS Cells IV. Immunophenotype of L&H Type RS Cells V. Nodular Lymphocyte-Predominance Hodgkin's Disease Cell Lines VI. Immunophenotype of B Cells VII. Immunophenotype of T Cells VIII. Relation to Progressively Transformed Germinal Centers IX. Large Cell Lymphomas X. Diffuse Variants of Nodular LPHD (Diffuse Paragranuloma) XI. Clinical Features of NLPHD XII. Conclusion ReferencesImmunophenotype of Reed-Sternberg Cells I. Introduction II. Activation Antigens III. Lymphoid Markers IV. Other Antigens V. Conclusion ReferencesThe Nature and Function of the Hodgkin's Cell Lectin and Its Role in Lymphocyte Agglutination I. Introduction II. Dual Role of the Hodgkin's Cell Lectin as Carbohydrate-Binding Protein and Ectosialyltransferase III. Relationship between the Hodgkin's Cell Lectin and the Hepatic Asialoglycoprotein Receptor IV. Subcellular Distribution of the Hodgkin's Cell Lectin V. Hodgkin's Cell Lectin as a Lymphocyte Agglutinant and Mitogen VI. Expression of the Hodgkin's Cell Lectin in Disease-Involved Human Tissues ReferencesRole of T Cells in the Pathogenesis off Hodgkin's Disease I. Introduction II. Possible Relationship between Immune Alterations and Pathogenesis of the Disease III. Pathogenic Hypothesis ReferencesGene Analysis and Epstein-Barr Viral Genome Studies of Hodgkin's Disease I. Introduction II. Antigen Receptor Gene Analysis of Hodgkin's Disease III. Molecular Studies of Epstein-Barr Virus in Hodgkin's Disease IV. In Situ Hybridization Studies for the Identification of Reed-Sternberg Cell mRNA: Interleukin-5 V. Studies on the Molecular Cytogenetics of Hodgkin's Disease ReferencesHodgkin's Disease: Analysis of Cell Line Data I. Introduction II. The Cell of Origin in Hodgkin's Disease III. The Cellular Pathogenesis of Hodgkin's Disease IV. Conclusions ReferencesIndexContents of Recent Volumes