Regulatory T Lymphocytes

Regulatory T Lymphocytes documents the proceedings of a symposium on ""Regulatory T Lymphocytes"" held at Arden House on the Harriman Campus of Columbia University from June 8-10, 1979. The meeting was the fourth of the P&S Biomedical Sciences Symposia. Starting with the opening address on regulatory T lymphocytes and their antigen receptors, the remainder of the book presents the contributions made by researchers at the symposium. These contributions are organized into seven parts. Part I contains studies T cell receptors. Part II presents studies on T cell subpopulations. Parts III and IV examine helper T cells. Parts V and VI deal with suppressor T cells. Part VII contains papers on regulatory T cell circuits.

List of Participants Preface Opening Address Regulatory T Lymphocytes and Their Antigen Receptors Introduction The Regulatory T Cells The T Cell Regulatory Networks The T Cell Receptor The Effect of Anti-Cri and Cri Coupled Cells on ABA DTH Hapten-Specific T Cell Responses to 4-Hydroxy-3-Nitrophenyl Acetyl (NP)-Genetic Control of DTH by VH and I-A Region Genes ReferencesPart I T Cell Receptors Generation and Analysis of T Cell Clones That Secrete Antigen-Specific Polypeptides Mediating Different T Cell Functions Introduction Results Discussion Conclusion References Immunochemical Properties of Isolated Hapten-Specific T Cell Receptor Molecules Introduction Material and Methods Results Discussion References Epitope-Binding Molecules from Azobenzenearsonate-Specific Murine T Cells Introduction Induction of ABA-Specific Helper and Suppressor Activity in A/J Mice Purification of ABA-Specific T Cells Properties of Affinity-Enriched ABA-Binding T Cells Biosynthetic Labeling of Cell Proteins with 35S-Methionine ABA-Specific Affinity Chromatography SDS-PAGE Analysis of T Cell-Derived ABA-Binding Molecules T Cell-Derived p92 Molecules Lack Classic Immunoglobulin Determinants Antigen-Specific Suppressor Activity of 92 KD T Cell Products Preparation of T Cell Hybrids T Cell Antigen Receptors and Effector Molecules References T Cell Mediated Immune Response to Anti-MHC Receptors Introduction Immunogenicity of Anti-MHC Receptors on T Cells Anti-MHC T Cell Receptors Display "Idiotypic" Determinants Which are Specificity Associated and Nonpolymorphic Induced Tolerance in F Rats to Anti-MHC Receptors on Parental T Cells Another Manifestation of Receptor Antigenicity Discussion References Part II T Cell Subpopulations Expression of la Antigens on T Lymphocytes Introduction Experiments with Functionally Defined T Cell Subpopulations Treatment with Anti-la Sera in Vivo Direct Evidence for the Expression of la Antigens on T Cells Conclusions References Analysis of Lymphocyte Subpopulations with Monoclonal Antibodies to Thy-1, Lyt-1, Lyt-2, and ThB Antigens Introduction Materials and Methods Results Discussion References Immunoregulation by Human Lymphocyte Subpopulations Introduction Normal Human B Cell Immunoregulation Abnormalities of Immunoregulatory T Cell Subpopulations in Selected Disease States Summary and Conclusions ReferencesPart III Helper T Cells (Murine) Regulation of the Immune Response to Cell Surface Antigens T -B Cooperation: Factors or Cell Contacts? Intrastructural, Intermolecular Help Intrastructural, Intermolecular Inhibition How Many Antigen-Presenting Cells? References Synergizing Helper T Cell Sets and the Regulation of Antibody Quality Introduction Results and Discussion Summary and Conclusions References Expression of Idiotype-Like Determinants on Hapten-Specific, MHC-Restricted T Helper Cells, Enrich in Vitro Introduction Methods and Results Discussion References Cooperation Subsets of Antigen -Specific Helper T Cells Methods and Results Discussion References T-B Collaboration in Vivo: Role of the Major Histocompatibility Complex Introduction Discussion References Functions of Two Helper T Cells Distinguished by Anti-la Antisera Introduction Materials and Methods