T-cell Activation in Health and Disease

T-cell Activation in Health and Disease is a collection of papers presented at the "T-cell Activation in Health and Disease-Disorders of Immune Regulation-Infection and Autoimmunity" workshop held in Oxford on September 25-29, 1988. This book discusses the progress occurring in T-cell immunity research. One paper discusses the effects of two interaction clones of T-cells that can define the T-cell immunoregulatory network. Another paper discusses the relationship between connectivity and tolerance of the immune network. This paper then suggests the possibility that autoimmunity arises because self-reactive clones are inadequately connected to the network. Another paper reviews the cell-mediated responses in the synovial fluids, as well as the interaction of rheumatoid arthritis synovial fluid dendritic cells and T lymphocytes. The book also examines why attempts for protective immunity to the HIV virus have not been successful. One article then discusses the goals of immunologic intervention in autoimmune disease by using an approach involving the cellular and cytokine targets and their deployment. This text can prove significant for scientists in the field of pharmacology, cellular biology, and researchers in the field of immunology and infectious diseases.

IntroductionT-cell Clone Anticlone Interactions. Effects on Suppressor and Helper ActivitiesThe Relationship Between Connectivity and Tolerance as Revealed by Computer Simulation of the Immune Network: Some Lessons for an Understanding of AutoimmunitySubsets of Rat CD4+ T Cells Express Different Variants of the Leukocyte-common Antigen: Functions and Developmental Relationships of the SubsetsCells in Health and DiseaseAntigen Processing: Current Issues, Exceptional Cases (Thy 1 Alloantigen, MHC Class-II-Restricted Cytolytic T Cells), and Implications for Vaccine DevelopmentTwo Distinct Mechanisms for Interleukin-2 Gene Expression in Human T LymphocytesThe 4F2 Heavy Chain Gene: a Molecular Model of Inducible Gene Expression in Human T CellsThe Importance of the Crystalline Surface Layer Protein Antigens of Rickettsiae in T-cell ImmunityThe Mycobacterial Groel Stress Protein: a Common Target of T-cell Recognition in Infection and AutoimmunityT-Cell Reactivity in Myasthenia GravisCloning and Characterization of Genes Coding for Turn" Transplantation AntigensThe Role of Class II Major Histocompatibility Complex Antigens in Autoimmune Diabetes: Animal ModelsFunctional and Phenotypic Properties of T-cell Clones which Regulate IgE SynthesisRole of Interleukin-4 in T-cell Ontogeny: Changes in Cell Surface Phenotype and Lymphokine Production of Immature Thymocytes after Culture with Interleukin-4 and Phorbol EsterEarly Events in Lymphopoiesis: the Role of Interleukins 1 and 7Inappropriate Expression of HLA Class II Molecules in Endocrine Epithelial Cells: The Phenomenon, the New Experimental Data and Comparison with Animal Models Intrathyroidal Cytokine Production in Thyroid DiseaseCytokine Production in Culture by Cells Isolated from the Synovial MembraneVirus-induced Autoimmunity: Molecular Mimicry as a Route to Autoimmune DiseaseMolecular Dissection of an Antigen-specific Immune ResponseFrequency of VH-gene Utilization in Human EBV-transformed B-cell Lines: The Most JH-proximal VH Segment Encodes AutoantibodiesA Role for MHC Class II Antigens in B-Cell ActivationAre Ly-1 B Cells Important in Autoimmune Disease?'Fetal-type' B and T Lymphocytes in Rheumatoid Arthritis and Primary Sjogren's SyndromeLimitations of the Anti-idiotype Strategy for an HIV VaccineHelper T-cell Determinants in Vaccine DesignThe Goals of Immunologic Intervention in Autoimmune Disease