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Teratogens Chemicals Which Cause Birth Defects, 2nd Revised Edition is a collection of papers that discusses the practical aspect of teratogens, particularly regarding information on the teratogenic potential of chemicals. This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and the role of bio-activation in teratogenesis. Investigations have been done on the relationship between spontaneous abortion in women exposed to organic solvents, antineoplastic agents, and chemicals in plastics. Other studies also show that teratogenicity depends in part on enzymatic bio-activation to an embryotoxic reactive intermediate. This text also explains the legal and ethical aspects of fetal protection policies with emphasis on fetal protection. Protection to expecting women extends to pregnant students exposed to teratogenic chemicals in chemistry laboratories. The book explains how and where to get information about the teratogenic potential of chemicals and how to properly handle these chemicals in the laboratory. The book also provides a list from RTECs of toxic chemicals which can cause reproductive effects. This book can prove useful for chemists, pharmacologists, obstetricians, gynecologists, and practitioners of general medicine.
Table of Contents1. Principles and Mechanisms of Teratogenesis2. Maternal Occupational Exposure and Spontaneous Abortion 3. Biochemical Determinants of Chemical Teratogenesis: Studies with Phenytoin, Benzo(A)Pyrene and Related Xenobiotics 4. Legal and Ethical Aspects of Fetal Protection Policies 5. Teratogenic Chemicals in Undergraduate Chemistry Laboratories6. How to Obtain Information About the Teratogenic Potential of Chemicals 7. Registry of Toxic Effects of Chemical Substances As A Source For Compiling A List of Teratogens List of Chemicals From RTECs which Cause Reproductive Effects 8. Safe Handling of Teratogenic Chemicals in the Laboratory Subject Index
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