The Inflammatory Process

The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from microvascular aspects of tissue injury and capillary permeability to rheologic factors in inflammation. The effects of inflammation on the lymphatic system are also explored, along with the sticking and emigration of white blood cells in inflammation. Comprised of 11 chapters, this volume begins with an overview of vascular events in the inflammatory process, paying particular attention to the microvascular aspects of tissue injury and structural and physiological considerations in capillary permeability. The rheology of inflammation and the effects of inflammation on the lymphatic system are also examined. Subsequent chapters focus on the natural role of amines, polypeptides, and proteases in the inflammatory process; mediation of increased vascular permeability in inflammation; and hemostatic mechanisms in tissue injury. The book concludes with an analysis of thrombosis as an initiator of inflammation and as a complication of inflammation, and how it can be prevented. This monograph will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.

List Of ContributorsPrefacePreface to First EditionContents of Other VolumesPart I. Vascular Events in the Inflammatory Process Chapter 1. Microvascular Aspects of Tissue Injury I. General Aspects of Reaction II. Specific Components III. Summary References Chapter 2. Capillary Permeability I. Structural Consideration I. Introduction II. Permeability of Capillaries III. Capillary Structure IV. Discussion of Various Mechanisms Proposed for the Control of Capillary Permeability V. Summary and Conclusions References Chapter 3. Capillary Permeability II. Physiological Considerations I. Introduction II. General Outline of Capillary Permeability III. Modes of Transport through Capillary Walls IV. Methods for Studying Diffusion Permeability of Capillaries References Chapter 4. Capillary Permeability III. Connective Tissue I. Historical Perspective II. Morphology and Composition of Connective Tissue III. Organization and Functions of Connective Tissue IV. Physical Chemistry of Connective Tissue V. Role of the Connective Tissue in Vascular Exchange VI. Reaction of Connective Tissue of Certain Agents VII. Connective Tissue Homeostasis References Chapter 5. Rheologic Factors in Inflammation I. Introduction II. Rheology of Normal Blood III. Rheology of Inflammation IV. Summary References Chapter 6. The Lymphatic System in Inflammation I. Introduction II. Structure III. Permeable Paths through the Lymphatic Wall IV. Functioning of the Lymphatic System V. Effects of Inflammation on the Lymphatic System VI. Effects of the Lymphatic System on Inflammation VII. Therapeutic Measures References Chapter 7. The Sticking and Emigration of White Blood Cells in Inflammation I. Introduction II. History of the Problem III. Fate of Emigrated Cells in the Extravascular Tissue IV. The Influence of pH on the Emigration of White Cells V. Relationship Between White Cell Sticking and Vascular Permeability VI. Chemotaxis VII. Electrochemical Factors VIII. Summary References Chapter 8. Chemical Mediators I. Introduction II. Early Vascular Events in Inflammation III. Endogenous Mediators of the Vascular Events IV. Evidence for the Natural Role of Amines, Polypeptides, and Proteases in the Inflammatory Process V. Inflammatory Response in Various Organs VI. Conclusions References Chapter 9. Mediation of Increased Vascular Permeability in Inflammation I. Introduction II. Acute Inflammation III. Trigger Mechanisms IV. Leukocytes as Mediators V. The Case against Mediators VI. Delayed Hypersensitivity VII. Unifying Hypothesis of Inflammation VIII. Conclusions Note Added in Proof ReferencesPart II. Hematological Considerations Chapter 10. Hemostatic Mechanisms in Tissue Injury I. Introduction II. The Hemostatic Plug III. Vascular and Tissue Factors in Hemostasis IV. Hemostasis as a Whole References Chapter 11. Thrombosis I. Thrombosis as an Initiator of Inflammation II. Thrombosis as a Complication of Inflammation III. Prevention of Thrombosis ReferencesAuthor IndexSubject Index