The Leukemias: Etiology, Pathophysiology, and Treatment

The Leukemias: Etiology, Pathophysiology, and Treatment documents the proceedings of an International Symposium on The Leukemias: Etiology and Pathophysiology, held at Henry Ford Hospital, Detroit, Michigan, 8-10 March 1956. This volume gives the present complex position of leukemic etiology and pathophysiologic disturbance, a much needed knowledge of detailed leukocytic functions and comprehensive thought on the therapy of the leukemias. It also establishes a basis of comparison with the earlier works of Downey and Forkner in this field in the late thirties and thus makes it possible to see with some clarity the extent of progress made. The volume contains 39 papers organized into nine parts. The papers in Part I focus on the leukemic cell, its structure, and antigenicity. Part II presents studies on genetic and environmental factors in the transmission of leukemia. Part III examines the radiation biology of leukocytes. Part IV focuses on the leukemias and the malignant lymphomas while Part V deals with leukocytic physiology. Part VI covers the metabolism of amino and nucleic acids in the leukemias. Part VII takes up further biochemical considerations in the leukemias. Part VIII contains papers that examine nucleic acids as the target for chemotherapy. Part IX presents a round-table discussion on therapy.

PrefacePart I: The Leulcemic Cell, Its Structure and Antigenicity 1. Electron Microscopy of Normal and Leulcemic Leukocytes Added Comment 2. Phase-Contrast Microscopy of Leukocytes Added Comment General Discussion 3. Antigenicity of Leukocyte Fractions 4. Some Studies on Leukocyte Agglutinins Added Comment General DiscussionPart II: Genetic and Environmental Factors in the Transmission of Leukemia 5. The Pathophysiology and Immunogenetics of Transplantable Leukemia 6. Genetic and Nongenetic Factors Influencing the Induction of Mouse Leukemia 7. Viral Etiology of Mouse Leukemia Added Comment General Discussion 8. Environmental Factors in Human LeukemiaPart III: Radiation Biology of Leukocytes 9. Radiation Injury and Regeneration in Lymphoid Tissues 10. Cytocidal Action of X-Rays on Lymphocytes According to Time-Lapse Cinemicrography and Unstained Cell Counts Added Comment Added Comment General DiscussionPart IV: The Leukemias and the Malignant Lymphomas 11. The Leukemias-Their Scope 12. The Malignant LymphomasPart V: Leukocytic Physiology 13. Cultivation of Leukemic Cells in the Cartesian Diver 14. Observations on Human Leukemic Cells in Culture 15. Newer Concepts of Leukopoiesis as Revealed by Leukopheretic and Isotopic Techniques 16. Endocrine Influences on Blood Formation Added Comment General Discussion 17. The Influence of Cellular Fractions of Whole Blood on the Course of Acute Lymphocytic Leukemia: A Preliminary Report 18. The Leukocytic Resistance Test General DiscussionPart VI: Metabolism of Amino and Nucleic Acids in the Leukemias 19. Some Aspects of Amino Acid Metabolism in Leukemia 20. Urinary Amino Acid Excretion in Leukemia 21. Free or Easily Extractable Amino Acids in Blood Cells and Body Fluids General Discussion 22. Metabolic Stability of PNA and DNA in Human Leukemic Leukocytes; The Function of Lymphocytes 23. Urinary Uric Acid Excretion in Leukemia 24. Nucleic Acids, Nucleases, and Nuclease Inhibitors in Leukemia 25. Studies on Cysteine Metabolism in Leukemia General DiscussionPart VII: Further Biochemical Considerations in the Leukemias 26. Immunologic Studies of Protein Synthesis in Leukemia 27. Biochemical and Enzymatic Characteristics of Normal and Leukemic Leukocytes (with Particular Reference to Leukocyte Alkaline Phosphatase) 28. Metabolism of Folic Acid and Citrovorum Factor in Leukemic Cells Added Comment: Labeling of RNA of Rabbit Peritoneal Exudate Polymorphonuclear Leukocytes General Discussion 29. Lactic Acid Production by Polymorphonuclear Leukocytes 30. Diagnostic and Nosological Problems at the Borderline of Leukemia General DiscussionPart VIII: Nucleic Acids as the Target for Chemotherapy: Mechanisms of Drug Action and Resistance 31. Nucleic Acids and Related Derivatives as Targets for Chemotherapy 32. Uracil Antagonists As Inhibitors of Transplantable Tumors 33. The Specific Action of Azaserine on Enzymes Concerned with Purine Biosynthesis 34. Nucleotide Metabolism and Cancer Chemotherapy General Discussion 35. Purine Nucleotide Biosynthesis and Neoplasia 36. Anticancer Agents and Nucleic Acid Metabolism of Isolated Human Leukocytes 37. Studies on Resistance to Folic Acid Antagonists 38. Metabolic and Nutritional Variations in Drug-Resistant Streptococcus Faecalis General Discussion 39. Round-Table Discussion on TherapyAuthor IndexSubject Index