The Macrophage In Neoplasia

The Macrophage in Neoplasia is a compilation of papers presented at a workshop held at the Marine Biological Laboratory, Woods Hole, Massachusetts, on October 8-11, 1975. The book presents the many faceted activities of macrophage. This book is divided according to the five sessions of the workshop. First session talks about the role of tumor macrophages in vivo. It then elucidates the macrophage function and indicates how the interaction of macrophages with other cells can alter the host-tumor balance. The remaining sessions, as presented in this book, explore the mechanism of macrophage mediated cytotoxicity, functional expression of macrophages and neoplasia, and the stimulation of macrophage function and applied therapy.

List of Participants PrefaceSession I: Role of Tumor Macrophages in Vivo Role of Macrophages in Host Defense Mechanisms Studies on the Hematogenous Dissemination of Technetium-99m Labeled Malignant Cells Tumor Macrophages in Host Immunity t o MalignanciesSession II: Macrophage Function and Interaction Introduction Defective Macrophage Migration Produced by Neoplasms: Identification of An Inhibiter of Macrophage Chemotaxis Macrophage Activation by Lymphocyte Mediators and Tumor Immunity: A Brief Review DiscussionSession III: Mechanisms of Macrophage Mediated Cytotoxicity The Macrophage as a Tumoricidal Effector Cell: A Review of in Vivo and in Vitro Studies on the Mechanism of the Activated Macrophage Nonspecific Cytotoxic Reaction Morphologic Aspects of Tumor Cell Cytotoxicity by Effector Cells of the Macrophage-Histiocyte Compartment: in Vitro and in Vivo Studies in BCG-Meditated Tumor Regression Mechanisms of Target Cell Destruction by Alloimmune Peritoneal MacrophagesCytostatic and Cytocidal Effects of Activated Nonimmune Macrophages DiscussionSession IV: Functional Expression of Macrophages and Neoplasia Human Pulmonary Macrophages in Disease and Neoplasia The Employment of Glucan and Glucan Activated Macrophages in the Enhancement of Host Resistance to Malignancies in Experimental Animals Macrophages in Regressing Progressing Moloney Sarcomas DiscussionSession V: Stimulation of Macrophage Function and Applied Therapy Introduction Peritoneal Macrophages from BCG-Infected Mice: Tumor Cytotoxicity and Chemotactic Responses in Vitro The in Vivo Destruction of Human Tumor by Glucan Activated Macrophages Macrophage Deficiency in Tumor Bearing Animals: Control of Experimental Metastasis With Macrophages Activated in Vitro Discussion Antagonism of Immunosuppression by BCG