Vascular and Neurological Changes in Early Diabetes

Advances in Metabolic Disorders, Supplement 2: Vascular and Neurological Changes in Early Diabetes covers knowledge of the vascular and neurological changes in early diabetes. The book discusses the prevalence of macroangiopathy in asymptomatic diabetes, the prevalence of asymptomatic diabetes in human atherosclerosis, and the observations made in seeking evidence for macroangiopathy, microangiopathy, and neurological changes in patients with latent diabetes. The text also describes angiopathy and neuropathy in mild juvenile diabetes; the role of insulin in the development of atherosclerosis; and the effect of insulin on lipid metabolism of human arteries. Discussions about microangiopathy, including topics on serum glycoprotein disturbances and their rheological effects in diabetes mellitus; the biochemical properties of human glomerular basement membrane in normal and diabetic kidneys; and the plasma levels of growth hormone and glucagon in diabetic patients and relatives of diabetic patients are also considered. The book further tackles topics about neuropathy, including the role of sorbitol pathway in neuropathy, the polyol pathway in the neuropathy of early diabetes, as well as nervous abnormalities in early diabetes. The text concludes by looking into the effect of treatment on diabetes. Endocrinologist, biochemists, physiologists, and researchers working on related topics will find the book useful.

List of ContributorsPrefaceAcknowledgmentsI. Macroangiopathy Macroangiopathy-Its Prevalence in Asymptomatic Diabetes The Prevalence of Asymptomatic Diabetes in Human Atherosclerosis A Search for Macroangiopathy in Patients with Latent Diabetes Angiopathy and Neuropathy in Mild Juvenile Diabetes Discussion The Role of Insulin in the Development of Atherosclerosis Effect of Insulin on Lipid Metabolism of Human Arteries Glucose Lipogenesis in Rabbit Aorta in Relation to Age, Degree of Atherosclerosis, and the Presence of Insulin Discussion Hypertriglyceridemia in Early Diabetes Altered Carbohydrate and Lipid Metabolism and Coronary Heart Disease among Men in Tecumseh, Michigan Insulin, Glucose and Lipid Levels in Mild Diabetics in Relation to Complications Invited Discussants Discussion Studies in the Functional Properties of Vascular Mucopolysaccharides Proline Hydroxylase in Injury-Induced Arteriosclerosis Polyol Pathway Activity in Aorta Invited Discussant Discussion Diabetic Macroangiopathy: Blood Flow and Radiological Studies DiscussionII. Microangiopathy Genetic Transmission of Vasculopathy in KK Mice Discussion The Metabolism of the Isolated Renal Glomerulus and Its Basement Membranes Serum Glycoprotein Disturbances and their Rheological Effects in Diabetes Mellitus Discussion Biochemical Properties of Human Glomerular Basement Membrane in Normal and Diabetic Kidneys Biochemistry of the Glomerular Basement Membrane in Diabetes Discussion Growth Hormone and Diabetic Angiopathy Comparative Metabolic and Clinical Studies of Sexual Ateliotic Dwarfs and Diabetics Plasma Levels of Growth Hormone and Glucagon in Diabetic Patients and Relatives of Diabetic Patients Discussion Plasma Epinephrine and Plasma Norepinephrine Concentrations in Early Diabetes Discussion Microangiopathy and Early Diabeticlike Sugar Tolerances in Animals with Induced Thyroid Immunity Microangiopathy in the Experimentally Diabetic Animal Vascular Changes Accompanying Dysmetabolism in Rabbits Microvascular Alterations in Chronically Streptozotocin-Diabetic Rats Discussion Ultrastructure of Glomerular Lesions in KK Mice Related Factors in the Progression of Microangiopathy in KK Mice Microangiopathy in Animals with Spontaneous Diabetes Retinal and Renal Microangiopathy in Carp with Spontaneous Diabetes Mellitus Invited Discussant Discussion Diabetic Basement Membranelike Changes Demonstrable in Perippheral Blood Lymphocytes Ophthalmoscopic Findings and Changes in Hormonal and Metabolic Parameters in "Protodiabetes Kidney Structural Abnormalities in Early Diabetes Invited Discussants Discussion The Capillaries of South African Diabetics in Perspective Diabetic Microangiopathy: Electron Microscope Findings in Human Muscle Capillary Basement Membrane Thickness in Early Diabetes Early Capillary Basement Membrane Changes in Subjects with Diabetes Mellitus Discussion Deterioration of Tolerance to Glucose and Progression of the Microangiopathy: Effect of Treatment (Preliminary Report) Microvascular Changes in Early Diabetes Mellitus Discussion Basement Membrane Thickening in Latent Diabetes The Microvascular Complications of Early Diabetes in the Pima Indians DiscussionIII. Neuropathy Role of Sorbitol Pathway in Neuropathy The Polyol Pathway in the Neuropathy of Early Diabetes Discussion Nervous Abnormalities in Early Diabetes Discussion Ultrastructural Pathology of Peripheral Nervous System in Early Diabetes Neurological Findings in Chemical Diabetes Neurological Changes in Early Diabetes Clinical Features of Peripheral Neuropathy Associated with Hypoglycemia Invited Discussants DiscussionIV.