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The following chapters provide excellent and comprehensive discussions of the potential role of vitamin D based therapies in breast, colorectal, prostate cancer and leukemia and myelodysplastic syndromes. These chapters also point out that the focus on these diseases is largely determined by the interests and expertise of the outstanding scientists who have chosen to pursue vitamin D based cancer therapeutics. To our knowledge, every tumor type ever evaluated has shown some biochemical and antiproliferative response to vitamin D. Similarly, vitamin D analogues, especially calcitriol, potentiate almost every cytotoxic agent with which combination therapies have been tested.
1. Vitamin D: Synthesis and Catabolism - Considerations for Cancer Causation and Therapy (Heide S Cross)2. Vitamin D Molecular Biology & Cancer (Moray J Campbell)3. Vitamin D: Anti-inflammatory activity of calcitriol in cancer (Aruna V Krishnan and David Feldman)4. Vitamin D & Cancer Epidemiology (Edward Giovannucci) 5. Vitamin D & Angiogenesis (Yingyu Ma, Donald L Trump and Candace S Johnson)6. Vitamin D: Cardiovascular Function and Disease (Robert Scragg) 7. Vitamin D & Differentiation in Cancer (Elzbieta Gocek and George P Studzinski) 8. Vitamin D & Cancer Chemoprevention (Sarah A Mazzilli, Mary E Reid and Barbara A Foster) 9. Molecular Biology of Vitamin D Metabolism and Skin Cancer (Florence SG Cheung and Juergen KV Reichardt)
INTRODUCTION - Vitamin D: Development as an Anticancer Agent (Donald L Trump and Candace S Johnson)
10. Vitamin D & Prostate Cancer (Tomasz M Beer) 11. Vitamin D & Hematologic Malignancies (H Phillip Koeffler) 12. The Vitamin D Signaling Pathway in Mammary Gland and Breast Cancer (Glendon M Zinser, Carmen J Narvaez and JoEllen Welsh) 13. Vitamin D & Colorectal Cancer (Marwan Fakih, Annette Sunga and Josephia Muindi) 14. Defining & Attaining Optimal Vitamin D Health (Reinhold Vieth) 15. Assessment of Vitamin D Health: Measurement of Vitamin D (Bruce W Hollis)