Advances in Metabolic Disorders

Advances in Metabolic Disorders, Volume 6 covers the developments in the study of metabolic disorders. The book discusses the role of the skin in carbohydrate metabolism; the transmission of Alloxan diabetes and other diabetogenic influences; and the association between glucagon levels and diabetes mellitus. The text also describes the recent contributions to the study of diabetic angiopathy and neuropathy; the disorders due to enzyme defects in the red blood cell; and the pineal gland as a neuroendocrine inducer. The basic aspects of the biology and physiology of calcitonin in relation to its hitherto acknowledged significance in clinical metabolic disorders are also considered. Endocrinologists, biochemists, pharmacologists, physicians, physiologists and medical students will find the book invaluable.

ContributorsContents of Previous VolumesThe Role of the Skin in Carbohydrate Metabolism I. Introduction II. Properties of Skin III. The Role of the Dermis in Glucose Homeostasis IV. Carbohydrate Metabolism of the Epidermis V. Sources of Energy in the Epidermis VI. Glucose/Lactate Balance in the Intact Animal VII. The Skin as an Indicator of Impaired Carbohydrate Metabolism VIII. Concluding Remarks Addendum ReferencesOn the Transmission of Alloxan Diabetes and Other Diabetogenic Influences I. Introduction-The Enigma of the Genetics of Human Diabetes II. The Question of Spontaneous and Experimentally Induced Diabetes in Animals III. Studies on Transmission of Experimental Diabetes Mellitus IV. Induction and Transmission of Latent Diabetes V. Pregnancy in Animals with Induced Carbohydrate Intolerance VI. Plasma Insulin in Animals with Induced Diabetes VII. Beta Cell Histology of Rats with Induced and Transmitted Diabetes VIII. Interpretation of the Data ReferencesGlucagon and Diabetes Mellitus I. Introduction II. Normal Alpha Cell Function III. Diabetic Ketoacidosis ReferencesRecent Contributions to the Study of Diabetic Angiopathy and Neuropathy I. General Characteristics of Diabetic Angiopathy and Neuropathy II. The Eye III. The Kidney IV. The Heart V. The Extremities VI. Capillary Resistance and Capillary Permeability VII. Diabetic Neuropathy VIII. Pathogenesis of Diabetic Angiopathy IX. Pathogenesis of Diabetic Neuropathy X. Prophylaxis and Therapy ReferencesDisorders Due to Enzyme Defects in the Red Blood Cell I. General Considerations II. Defects of the Embden-Meyerhof Pathway III. Deficiencies in the Hexose Monophosphate and Related Pathways IV. Other Enzyme Defects Associated with Hematologic Disease ReferencesThe Pineal Gland-A Neuroendocrine Transducer I. Introduction II. Effects on the Reproductive System III. Effects on the Adrenal Glands IV. Effects on the Thyroid Gland V. Effects on Growth and Growth Hormone VI. Nonendocrine Effects VII. Conclusions ReferencesCalcitonin in Metabolic Disorders I. Calcitonin in the Scheme of Calcium Homeostasis II. Nature of Calcitonin and Its Action III. Clinical Considerations IV. Summary ReferencesAuthor IndexSubject Index

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