From Molecules to Networks

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease.- Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook- Discusses emerging new understanding of non-classical molecules that affect neuronal signaling- Full colour, professional graphics throughout- Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer's disease

1. Cellular Components of Nervous TissuePatrick R. Hof, Esther A. Nimchinsky, Grahame Kidd, Luz Claudio, and Bruce D. Trapp2. Subcellular Organization of the Nervous System: Organelles and Their FunctionsScott Brady, David R. Colman, and Peter Brophy 3. Energy Metabolism in the Brain Gerald A. Dienel4. Electronic Properties of Axons and DendritesJohn H. Byrne and Gordon M. Shepherd5. Membrane Potential and Action PotentialDavid A. McCormick 6. Molecular Properties of Ion ChannelsDavid Matthew Young, Yuh Nung Jan, and Lily Yeh Jan 7. Dynamical Properties of Excitable MembranesDouglas A. Baxter and John H. Byrne 8. Release of NeurotransmittersRobert S. Zucker, Dimitri M. Kullmann, and Thomas L. Schwarz 9. Pharmacology and Biochemistry of Synaptic Transmission: Classic TransmittersAriel Y. Deutch and Robert H. Roth10. Peptides, Growth Factors, Gasses and Other NeurotransmittersAriel Y. Deutch, Andrea Giuffrida and James L. Roberts 11. Neurotransmitter ReceptorsM. Neal Waxham 12. Intracellular SignallingHoward Schulman 13. Regulation of Neuronal Gene Expression and Protein SynthesisJames L. Roberts and James R. Lundblad 14. Mathematical Modeling and Analysis of Intracellular Signaling PathwaysPaul D. Smolen, Douglas A. Baxter, and John H. Byrne15. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and MoreJuan C. Sáez and Bruce J. Nicholson16. Postsynaptic Potentials and Synaptic IntegrationJohn H. Byrne 17. Complex Information Processing in DendritesJohn H. Byrne and Gordon M. Shepherd18. Information Processing in Neural NetworksJames J. Knierim 19. Learning and Memory: Basic MechanismsJohn H. Byrne, Kevin S. LeBar, Joseph E. LeDoux, Glenn E. Schafe, Richard F. Thompson, and J. David Sweatt 20. Molecular and Cellular Mechanisms of Neurodegenerative DiseaseMark R. Cookson, Randy Strong, P. John Hart, and James L. Roberts