The Immune System and Mental Health

The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry.Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson's and Alzheimer's-like dementia are explored.
- Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan- Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences- Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health

Hymie Anisman received his PhD from the University of Waterloo, where he was also on faculty for two years, and has been a Professor at Carleton University, since 1994. He has also held an adjunct appointment with the Institute of Mental Health Research (Royal Ottawa Hospital) since 1993. Professor Anisman was a Senior Ontario Mental Health Research Fellow, is a Fellow of the Royal Society of Canada, and held a Canada Research Chair in Neuroscience from 2001-2015, and has since held the position of Canada Research Professor. The principle theme of his research has concerned the influence of stressors on neurochemical, neuroendocrine and immune systems, and how these influence psychological (anxiety, depression) and physical illnesses including neurodegenerative, heart disease, and cancer progression.Shawn Hayley is a Full Professor and previous Canada Research Chair in the Department of Neuroscience at Carleton University. Some of his research examines how the immune system influences neuroplasticity of the brain and consequently, how could be important for the development of new antidepressant drugs. As well, Dr. Hayley has been focused on how inflammation within the brain can cause neuronal degeneration and contribute to the onset and progression of Parkinson's disease. The Hayley lab is involved in studies in assessing how chemical (e.g. pesticides) immunologic (e.g. viral, bacterial agents) and even psychological environmental stressors can contribute to the development of Parkinson's disease, as well as it comorbid states (e.g. depression, anxiety). Much of this research is focused on how the brain's specialized immune cells, the microglia, are involved in the generation of neuronal pathology, as well as possibly recovery from pathology.Alex Kusnecov received his doctorate from the University of Newcastle, New South Wales, Australia, after which he conducted postdoctoral research in psychoneuroimmunology at the University of Rochester. Subsequently, he held a faculty appointment in the Department of Pathology, University of Pittsburgh Medical Center, USA. He is currently a Professor within the Department of Psychology at Rutgers University, where his research involves the analyses of functional relationships between the brain and behavior, endocrine systems, and immune processes. His research on psychoneuroimmunology has appeared in prestigious journals, and together with Dr. Anisman, he has published two books (one an edited volume, and the other a text dealing with the involvement of the immune system in mental illnesses and neurodegenerative disorders). His research is funded by the National Institutes of Mental Health (NIMH). He serves on the editorial board of Brain, Behavior and Immunity, and has served on several National Institute for Health research grant panels, and has reviewed grants for Canadian and European grant agencies. He has acted as undergraduate director of the Department of Psychology, and currently co-chairs the Department of Psychology Diversity and Climate Committee.

1. Multiple Pathways Linked to Mental Health and Illness2. The Immune System: An Overview3. Bacteria, Viruses, and the Microbiome4. Life-Style Factors Affecting Biological Processes and Health 5. Stressor Processes and Effects on Neurobiological Functioning6. Stress and Immunity7. Prenatal and Early Postnatal Influences on Health8. Depressive Disorders9. Anxiety Disorders10. Posttraumatic Stress Disorder11. Pain Processes12. Autism13. Schizophrenia14. Inflammatory Roads to Parkinson's Disease15. A Neuroinflammatory View of Alzheimer's Disease16. Comorbidities in Relation to Inflammatory processes

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