Molecular Exercise Oncology

Molecular Exercise Oncology breaks down the cellular and molecular mechanisms underlying the benefits of different types of physical activity-from aerobic and resistance exercise to simple daily activities-including key scientific findings that provide insights into the foundational concepts of modern exercise oncology, revealing exercise as a potent tool throughout the cancer continuum. This book uncovers the evidence underpinning primary cancer prevention, how physical activity and exercise can improve treatment outcomes, reduce secondary recurrence risk and enhance quality of life (QoL). With practical resources and pedagogical features, this text serves as an accessible and engaging key text to support student learning and to redefine the way exercise as medicine is perceived, in that every step counts in the battle against cancer. For students studying sport and exercise science, clinical exercise physiology and exercise as medicine, for researchers in the field and for clinicians working with patients, Molecular Exercise Oncology offers invaluable insights into the latest findings in physical activity, exercise and cancer, with additional perspectives on the cellular and molecular basis of exercise as medicine.

Mhairi A. Morris, PhD, is a Reader in Exercise Oncology at Loughborough University, UK, where she teaches cancer biology and conducts research into the obesogenic breast cancer microenvironment using novel 3D co-culture models to explore the effects of exercise and endocrine-disrupting chemicals on breast cancer growth and metastasis. Mhairi is a two-time recipient of the Eric Reid Methodology Award and has received numerous awards for her innovative teaching methods in cancer biology, including gamification and VR technology. She earned a PhD in tumour virology at the University of Birmingham in 2009 and pivoted her research focus to exercise oncology in 2017 after joining Loughborough University. Outside of academia, Mhairi is a certified Les Mills Dance(TM) and BodyJam(TM) instructor, teaching four classes a week. Dance has become an integral part of her life, combining her enthusiasm for exercise with her academic pursuits.

1. Introduction to physical activity, exercise and cancer. Part I: Exercise and cancer. 2. The evidence behind exercise versus sedentary behaviour and cancer. 3. The cellular response to exercise in cancer. 4. The molecular basis of exercise in cancer. Part II: FITT for life. 5. Types of exercise and their benefits. 6. Differential effects of exercise intensities. 7. Frequency and length of exercise bouts. Part III: Current guidelines. 8. Exercise guidelines and recommendations. 9. A new perspective on exercise and cancer. 10. Additional resources.