Vitamin E in Human Health

This comprehensive volume examines the role of vitamin E as an essential micronutrient in human health and its extensive clinical benefits. Sections cover a wide breadth of topics, including vitamin E intake and recommended daily allowance, understanding the biological activities of Vitamin E and observed physiological effects, benefits of vitamin E on upper respiratory infections, cardiovascular disease, age-related macular degeneration, Alzheimer's disease, and intake safety. The text serves to emphasize the importance of vitamin E in relation to disease prevention as well as to raise awareness of the number of health conditions where an increased intake of vitamin E can be of potential significance. It explores vitamin E in an up-to-date, science based, applicable real-life perspective and offers pragmatic solutions for its safe and personalized use beyond the various methodological and statistical controversies. Intended for the medical and nutritional community, Vitamin E in Human Health will not only be an expansive resource for healthcare professionals, but also makes efforts to stimulate increased support for vitamin E research and further exploration of the safe and efficacious use for this essential micronutrient.

Peter WeberInstitute of Biological Chemistry and NutritionUniversity of HohenheimStuttgart, Germany Marc BirringerDepartment of Nutritional, Food and Consumer SciencesFulda University of Applied SciencesFulda, Germany Jeffrey B. Blumberg,PhD, Jean Mayer USDA Human Nutrition Research Center on AgingFriedman School of Nutrition Science and PolicyTufts University Manfred Eggersdorfer DSM Nutritional ProductsKaiseraugst, Switzerland Jan FrankInstitute of Biological Chemistry and NutritionUniversity of HohenheimStuttgart, Germany

Introduction.- History of Vitamin E Research.- Antioxidative Activity of Vitamin E.- Bioavailability and Metabolism of Vitamin E.- Occurrence and Bioactivities of Minor Vitamin E Derivatives.- Bioactivity of Vitamin E Long-Chain Metabolites.- Gene-regulatory Activity of Vitamin E.- Metabolomic Approaches in Vitamin E Research.- The Tocopherol Transfer Protein: Regulator of Vitamin E Status.- The Role of Lipid Rafts in Mediating the Anticancer Effects of y-Tocotrienol.- Interaction between Vitamin E and Polyunsaturated Fatty Acids.- The Challenge of Defining Daily Intake Recommendations: Vitamin E and Polyunsaturated Fatty Acids.- Vitamin E Intake and Serum Levels in the General Population: a Global Perspective.- Vitamin E Serum Levels and the Challenge to Correct for Lipids: Accounting for the Usual Double Correction for Variance shared by Total Cholesterol and Fasting Triglycerides Reveals New Insights into the Association with the One Carbon Pathway.- Stability of Vitamin E in Foods.- Vitamin E and Mortality: A Critical Perspective of the Conflicting Meta-Analysis Outcomes.- Vitamin E: Drug Interactions.- Vitamin E: Interactions with Vitamin K and other Bioactive Compounds.- Clinical Cardiovascular Disease Trials: The Vitamin E Case.- Haptoglobin Genotype and a Promising Pharmacogenomic Approach to Prevent Diabetic Atherothrombosis with Vitamin E Supplementation.- Vitamin E and Metabolic Syndrome.- Vitamin E in nonalcoholic Fatty Liver Disease.- The Role of Vitamin E in Aging and Alzheimer's Disease.- The Impact of Vitamin E Isoforms on Asthma and Allergy.- Vitamin E, Immune Function, and Protection Against Infection.- Vitamin E and Air Pollution.- The Role of Vitamin E in Pregnancy.- Vitamin E and Health Care Costs: Models to Assess the Impact.- Do Consumers Care about Micronutrients? A Perspective on the Possible Role of Vitamin E in the Dietary Choices of Consumers.- Addressing Key Knowledge Gaps in Nutrition and the Impact of Funding Priorities in Human Nutrition.